Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens

Table 2 Body weight (BW) and seminal vesicle weight of InT-control, CsX, CsX-TRT, CsX-DRT, CsX-LST, CsX-LST-TRT, and CsX-TRT-Tfm male rats

Group	Week 0, BW (g)	Week 10, BW (g)	Week 15, BW (g)	Seminal vesicle (g·100 g of BW⁻¹)
InT-control	339 ± 8^a+	433 ± 12^a#	439 ± 14^a#	0.29 ± 0.013^a
CsX	383 ± 22^b+	457 ± 22^a#	458 ± 27^a#	0.02 ± 0.001^c
CsX-TRT	374 ± 7^b+	433 ± 7^a#	446 ± 8^a#	0.33 ± 0.018^a
CsX-DRT	519 ± 13^c+	594 ± 17^c#	670 ± 26^c*	0.10 ± 0.003^d
CsX-LST	385 ± 4^b+	456 ± 8^a#	462 ± 11^a#	0.03 ± 0.001^b
CsX-LST-TRT	374 ± 3^b+	432 ± 4^a#	453 ± 5^a*	0.34 ± 0.025^a
CsX-TRT-Tfm	401 ± 23^b+	487 ± 16^b#	525 ± 20^b#

Male Sprague-Dawley (SD) rats: intact (InT), bilaterally castrated (CsX), and CsX with TES therapy (CsX-TRT; 1.75 mg kg⁻¹; sc, 2x/week) or DHT therapy (CsX-DRT;1.00 mg kg⁻¹; sc, 2x/week). In a separate experiment, CsX males were given losartan drinking water (250 mg L⁻¹) without (CsX-LST) or with TES therapy (CsX-LST-TRT; 1.75 mg kg⁻¹; sc, 2x/week). Testicular feminized male (Tfm) rats were castrated and given TES therapy (CsX-TRT-Tfm). Data are means ± SEM (n = 6-13 rats per group).
^a-cMean values within each column for BW (week 0, 10, and 15) and seminal vesicle weight without common superscript are significantly different (0.0001 ≤ P ≤ 0.02)
^{+, #, *}Mean values for BW within each row for each of the experimental groups (InT-control, CsX, CsX-TRT, CsX-DRT, CsX-LST, CsX-LST-TRT, and CsX-TRT-Tfm) over time (week 0, 10, and 15) without common superscript are significantly different (0.0001 ≤ P ≤ 0.02)

ISSN: 2042-6410