Fig. 5

Common and unique DEPs detected during hepatocarcinogenesis in males and females. a Venn analysis for DEPs detected in the proteomics for males and females, respectively. The slash symbol means “versus”. b DEPs were divided into the different expression patterns in males and females, respectively, and then overlap the DEPs within the same pattern between males and females to determine common and unique DEPs correlated with hepatocarcinogenesis and/or the expression of the Hras12V oncogene. HCC positive-correlated (a) or negative-correlated (c) proteins represent that these proteins were significantly increased or decreased in T comparing with those in P and/or W, respectively. The Hras12V oncogene positive-correlated (b) or negative-correlated (d) proteins represent that these proteins were significantly increased or decreased in P and T when compared with those in W, respectively. In the schematic diagram of the expression pattern, the numbers 1, 2, and 3 represent the graded and significant expression levels. The colored columns represent the significantly changed expression levels comparing with at least one group in the same pattern, and the white column indicates no significant expression changes comparing with those of the other two groups. The deep red-colored boxes indicate completely overlapping DEPs between sexes in the same expression pattern. The light red boxes indicate DEPs with similar expression patterns. The blue boxes indicate unique DEPs between sexes. The abbreviation and symbol definitions as well as descriptions are the same as those in the caption for Fig. 1