A new sex-specific underlying mechanism for female schizophrenia: accelerated skewed X chromosome inactivation

Table 2 The relationship between the degree of skewed XCI and clinical symptoms in SCZ

SCZ patient		Patient age (years)	Age of onset (years)	Disease duration (months)	PPANSS^†	NPANSS^§	Total PANSS	Medicine (mg/day)
Total patient	Coefficient	0.312	0.317	−0.053	0.1	−0.103	0.041	0.019
	Significance	0.001	0.001	0.605	0.326	0.311	0.687	0.88
Child patient	Coefficient	0.132	0.212	−0.219	0.046	−0.281	−0.061	−0.052
	Significance	0.421	0.195	0.180	0.783	0.083	0.711	0.771
Adult patient	Coefficient	0.129	0.126	−0.198	0.299	0.077	0.223	0.286
	Significance	0.391	0.402	0.193	0.046	0.614	0.142	0.236
Elderly patient	Coefficient	0.127	0.345	−0.359	0.282	0.274	0.248	0.388
	Significance	0.64	0.208	0.188	0.308	0.322	0.372	0.153

The relationship between degree of skewed XCI and clinical indicators analyzed by Spearman's correlation and Spearman's correlation was significant at p < 0.0167 for age group of SCZ patients.
†Positive symptoms in the PANSS
§Negative symptoms in the PANSS

ISSN: 2042-6410