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Table 2 The relationship between the degree of skewed XCI and clinical symptoms in SCZ

From: A new sex-specific underlying mechanism for female schizophrenia: accelerated skewed X chromosome inactivation

SCZ patient Patient age (years) Age of onset (years) Disease duration (months) PPANSS NPANSS§ Total PANSS Medicine (mg/day)
Total patient Coefficient 0.312 0.317 −0.053 0.1 −0.103 0.041 0.019
  Significance 0.001 0.001 0.605 0.326 0.311 0.687 0.88
Child patient Coefficient 0.132 0.212 −0.219 0.046 −0.281 −0.061 −0.052
  Significance 0.421 0.195 0.180 0.783 0.083 0.711 0.771
Adult patient Coefficient 0.129 0.126 −0.198 0.299 0.077 0.223 0.286
  Significance 0.391 0.402 0.193 0.046 0.614 0.142 0.236
Elderly patient Coefficient 0.127 0.345 −0.359 0.282 0.274 0.248 0.388
  Significance 0.64 0.208 0.188 0.308 0.322 0.372 0.153
  1. The relationship between degree of skewed XCI and clinical indicators analyzed by Spearman's correlation and Spearman's correlation was significant at p < 0.0167 for age group of SCZ patients.
  2. †Positive symptoms in the PANSS
  3. §Negative symptoms in the PANSS