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Table 5 Data presentation

From: Systematic review supports the role of DNA methylation in the pathophysiology of preeclampsia: a call for analytical and methodological standardization

Data presentation n %
Methylation quantified by
β value 19 21.1
Δβ 15 16.7
Adjusted Δβ 1 1.1
Δβ fold change 1 1.1
Fold change 4 4.5
Relative fold change 1 1.1
Log2 ratio 7 7.8
Log2 fold change 1 1.1
%* 71 78.9
M value (logit transformed β) 3 3.3
Diff score 1 1.1
Ct (ΔCt, 2- ΔCt) 2 2.2
H-score 1 1.1
Positive for methylation 1 1.1
Number of copies/mL 2 2.2
Error presented (sd, se, iqr, 95%CI, range) 50 55.5
Individual data 13 14.4
Methylation reported in
Main text
Table 36 40.0
Figure 70 77.8
In text only 2 2.2
Supplement 17 18.9
Not reported at all 1 1.1
Repository 11 12.2
  1. β value is an estimate of methylation level using the ratio of intensities between methylated and unmethylated alleles β = methylated allele intensity (M)/(unmethylated allele intensity (U) + methylated allele intensity (M) + 100); *%, mean methylation %, % change in methylation, % of methylated/unmethylated, % hypermethylated; using the Illumina Custom Algorithm a Diff score is calculated from the p value of significance: DiffScore = (10sgn(Icond-Iref)log10(p)); Ct value is a relative measure of DNA methylation level that denotes which cycle the fluorescence goes over a certain threshold value; H-score is the product of the percentage of cells in each sample with positive staining (range, 0–100%) multiplied by the intensity of staining (range, 0–3); sd, standard deviation; se, standard error; iqr, interquartile range