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Table 5 Data presentation

From: Systematic review supports the role of DNA methylation in the pathophysiology of preeclampsia: a call for analytical and methodological standardization

Data presentation

n

%

Methylation quantified by

β value

19

21.1

Δβ

15

16.7

Adjusted Δβ

1

1.1

Δβ fold change

1

1.1

Fold change

4

4.5

Relative fold change

1

1.1

Log2 ratio

7

7.8

Log2 fold change

1

1.1

%*

71

78.9

M value (logit transformed β)

3

3.3

Diff score

1

1.1

Ct (ΔCt, 2- ΔCt)

2

2.2

H-score

1

1.1

Positive for methylation

1

1.1

Number of copies/mL

2

2.2

Error presented (sd, se, iqr, 95%CI, range)

50

55.5

Individual data

13

14.4

Methylation reported in

Main text

Table

36

40.0

Figure

70

77.8

In text only

2

2.2

Supplement

17

18.9

Not reported at all

1

1.1

Repository

11

12.2

  1. β value is an estimate of methylation level using the ratio of intensities between methylated and unmethylated alleles β = methylated allele intensity (M)/(unmethylated allele intensity (U) + methylated allele intensity (M) + 100); *%, mean methylation %, % change in methylation, % of methylated/unmethylated, % hypermethylated; using the Illumina Custom Algorithm a Diff score is calculated from the p value of significance: DiffScore = (10sgn(Icond-Iref)log10(p)); Ct value is a relative measure of DNA methylation level that denotes which cycle the fluorescence goes over a certain threshold value; H-score is the product of the percentage of cells in each sample with positive staining (range, 0–100%) multiplied by the intensity of staining (range, 0–3); sd, standard deviation; se, standard error; iqr, interquartile range