Fig. 2
From: Sex differences in Alzheimer’s-related Tau biomarkers and a mediating effect of testosterone
Relationship between plasma testosterone levels and CSF p-Tau levels overall (a) and by APOE4 status (b). Using multivariable linear regression, we found a significant total testosterone X APOE4 status interaction on p-Tau levels that revealed an association between lower total testosterone levels and higher p-Tau levels among APOE4 carriers (n = 93) but not among APOE4 non-carriers (n = 79). CSF cerebrospinal fluid, p-Tau phosphorylated Tau, APOE4 apolipoprotein E ε4 allele. Analyses covaried for age, sex, education, BMI, and self-reported history of cardiovascular events