From: Sex-specific clustering of metabolic risk factors and cancer risk: a longitudinal study in Iran
Variables | Cluster 1 (n = 674) | Cluster 2 (n = 411) | Cluster 3 (n = 498) | Cluster 4 (n = 672) | Cluster 5 (n = 456) | Cluster 6 (n = 375) | Cluster 7 (n = 843) | *P value |
---|---|---|---|---|---|---|---|---|
Age (years) | 53.5(12.4) | 52.3(13.1) | 52.4(14.2) | 51.0(13.4) | 42.4(9.8) | 40.8(9.3) | 43.6(11.5) | < 0.001 |
Education | ||||||||
 Level 1 (0–8 years) | 520(77.2) | 324(78.8) | 373(74.9) | 507(75.4) | 354(77.6) | 291(77.6) | 634(75.2) | < 0.001 |
 Level 2 (9–12 years) | 98(14.5) | 54(13.1) | 79(15.9) | 113(16.8) | 89(19.5) | 78(20.8) | 173(20.5) | |
 Level 3 (> 12 years) | 56(8.3) | 33(8.1) | 46(9.2) | 52(7.8) | 13(2.9) | 6(1.6) | 36(4.3) | |
Physical activity level | ||||||||
 Low physical activity | 490(72.7) | 287(69.8) | 326(65.5) | 498(74.1) | 343(75.2) | 279(74.4) | 627(74.4) | 0.005 |
Smoking | ||||||||
 Never | 291(43.2) | 173(42.1) | 207(41.6) | 296(44.0) | 161(35.3) | 134(35.7) | 256 (30.3) | < 0.001 |
 Past | 133(19.7) | 77(18.7) | 89(17.9) | 125(18.6) | 68(14.9) | 48(12.8) | 111(13.2) | |
 Passive | 73 (10.8) | 50(12.2) | 59(11.8) | 102(15.2) | 66(14.5) | 57(15.2) | 95 (11.3) | |
 Current | 177(26.3) | 111(27.0) | 143(28.7) | 149(22.2) | 161(35.3) | 136(36.3) | 381(45.2) |  |
BMI (kg/m2) | 27.6(3.9) | 26.7(4.1) | 26.2(3.7) | 27.1(3.8) | 28.2(2.6) | 27.9(2.2) | 22.1(2.1) | < 0.001 |
FPG (mmol/L) | 7.4(2.7) | 7.1(2.3) | 4.9(0.3) | 4.9(0.3) | 4.9(0.4) | 4.9(0.3) | 4.8(0.3) | < 0.001 |
TC (mmol/L) | 6.2(0.8) | 4.4(0.5) | 4.4(0.5) | 6.1(0.8) | 6.0(0.8) | 4.4(0.5) | 4.9(1.0) | < 0.001 |
SBP (mmHg) | 130.2(21.2) | 127.8(20.7) | 135.8(16.3) | 134.0(14.7) | 109.2(6.7) | 108.5(7.5) | 106.4(8.2) | < 0.001 |
Mean number of risk factors | 3.4(0.7) | 2.2(0.7) | 1.6(0.5) | 2.7(0.5) | 2.0(0.0) | 1.0(0.0) | 0.4(0.4) | < 0.001 |
HBMI | 511(75.8) | 277(67.4) | 302(60.6) | 486(72.3) | 456(100) | 375(100) | 0(0.0) | < 0.001 |
HSBP | 450(66.8) | 256(62.3) | 498(100) | 672(100) | 0(0.0) | 0(0.0) | 0(0.0) | < 0.001 |
HTC | 674(100) | 0 (0.0) | 0 (0.0) | 672 (100) | 456 (100) | 0(0.0) | 351(41.6) | < 0.001 |
HFPG | 674(100) | 411(100) | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | < 0.001 |
Number of events | 29 | 16 | 30 | 27 | 4 | 8 | 18 | Â |
Incident rate of cancers (CI), per 1000 person years | 3.6(2.5–5.2) | 3.4(2.0–5.5) | 5.1(3.6–7.3) | 3.2(2.2–4.7) | 0.6(0.2–1.8) | 1.7(0.8–3.5) | 1.7(1.1–2.7) |  |