Fig. 5

Heme-mediated actin remodeling mechanisms in the MCT model. Our data indicate that the level of HSP27 involved in actin fibers formation was highly elevated in the lungs of male rats after MCT treatment (a). This correlated with increased phosphorylation of MLC (b). Barrier protective small GTPase, Rac1, was significantly decreased in MCT males (c). Mean ± SEM, N = 4, *p < 0.05,**p < 0.01 vs control, t test