Fig. 2

Module enrichment plot for PTSD-relevant modules identified in network analyses of hippocampus. Analyses on full expression dataset (both sexes) that has been a unadjusted for cell proportion estimates or surrogate variable (SV) estimates; b adjusted for cell proportion estimates; c adjusted for SV estimates. a Unadjusted: Module M2 consists of 104 genes; upregulation in EBR and downregulation in MBR groups in both sexes, and downregulation in female CON group. b Cell-adjusted: Module M1 consists of 165 genes; upregulation in female EBR and male MBR groups with relative downregulation in CON group in both sexes. c SV-adjusted: Module M1 consists of 81 genes; upregulation in female EBR and downregulation in female CON group. The size and intensity of the circles correspond to the normalized enrichment score (NES) for the module in each sex-stratified group (normalized by the number of genes in the module)