Fig. 2

The distribution of immune system-related genes (ISRG) over the sex chromosomes. The genes are within colour-coded rows to indicate their main function. The font colour of each gene is according to their level of XCI or XCI escape probability and PARs are enclosed in a dashed box. Most ISRG involve various immune functions simultaneously, e.g. SASH3 may be a signal adapter in lymphocytes that regulates apoptosis and proliferation in both innate and adaptive immunity affecting both cellular and humoral immunity. Such cases were assigned to the main function in the distribution of ISRG over the sex chromosomes (a), but placed in the intersection of proliferation/apoptosis, innate and signal transduction in the Venn diagram (b). The Venn diagram should be considered the best possible approximation rather than an exact function annotation