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Table 3 Associations with high Gal3BP for all, women and men

From: Female sex, high soluble CD163, and low HDL-cholesterol were associated with high galectin-3 binding protein in type 1 diabetes

Variables High galectin-3BP (≥3.3 mg/l, ≥80th percentile)
All patients Women Men
COR p value AOR p valuea AOR p valueb AOR p valuec
Sex (women) 2.7 (1.5–4.9) 0.001 3.0 (1.5–5.9) 0.001
Age 0.99 (0.97–1.02) 0.43 1.02 (0.99–1.05) 0.22 0.98 (0.94–1.02) 0.27 1.03 (0.98–1.08) 0.30
Diabetes duration 0.98 (0.95–1.00) 0.076 0.98 (0.95–1.00) 0.11 0.96 (0.92–1.01) 0.14
sCD163 (mg/l) 5.4 (1.6–18.0) 0.005 6.6 (1.9–23.2) 0.003 4.6 (0.8–26.9) 0.093 11.2 (2.0–64.5)) 0.007
Galectin-3 (μg/l) 1.04 (0.99–1.10) 0.14
HbA1c mmol/mol 1.03 (1.01–1.05) 0.008 1.02 (1.00–1.04) 0.09 1.03 (1.00–1.06) 0.039
TC (mmol/l) 1.4 (1.0–1.8) 0.022 1.6 (1.1–2.2) 0.007 2.3 (1.3–3.9) 0.003
Triglycerides (mmol/l) 1.5 (1.1–2.1) 0.014 0.9 (0.5–1.5) 0.58 0.7 (0.4–1.5) 0.41
LDL-cholesterol (mmol/l) 1.5 (1.1–2.2) 0.017 0.6 (0.1–3.5) 0.53 1.1 (0.6–1.8) 0.76 0.4 (0.03–6.6) 0.56
HDL-cholesterol (mmol/l) 0.45 (0.2–1.0) 0.059 0.2 (0.1–0.7) 0.010 0.2 (0.02–0.9) 0.040
Creatinine 0.99 (0.97–1.01) 0.16
Abdominal obesity 1.1 (0.5–2.4) 0.77
General obesity 3.4 (1.6–7.2) 0.002 1.6 (0.7–4.0) 0.29 7.9 (1.9–32.6) 0.004
SBP 0.99 (0.96–1.01) 0.26
DBP 1.00 (0.96–1.04) 0.83
Smoking 1.2 (0.5–3.1) 0.74
Physical inactivity 2.3 (1.0–5.2) 0.053 1.8 (0.7–4.8) 0.22
Depression 0.6 (0.2–1.3) 0.19
CV complications 2.7 (0.7–9.8) 0.14 4.0 (0.3–47.3) 0.26
Diabetes retinopathy 1.0 (0.5–2.0) 0.93
Foot complications 1.3 (0.6–2.7) 0.54
AD 1.8 (0.7–4.5) 0.24 2.6 (0.7–9.4) 0.15
AHD 0.9 (0.5–1.7) 0.79
LLD 1.2 (0.7–2.2) 0.47
  1. a, b, c Logistic regression analyses (Backward: Wald): variables with p values ≤0.10 for the CORs and age were included in the analyses; N = a 267/b 123/c 160; Nagelkerke R2: a 0.206/ b 0.089/c 0.298; Hosmer-Lemeshow test: a 0.991/b 0.142/c 0.821