Fig. 4

Systolic blood pressure (SBP) response to acute AngII challenge is augmented in obese female, but not obese male mice with adipocyte-ACE2 deficiency. At 4 months of HF feeding, the time course of SBP following an acute injection (sc) of AngII (20 μg/kg) to female Ace2^fl/fl (a) or male Ace2^fl/y (b) and Ace2^Adipo mice. Data are reported as the average blood pressure per minute at each time point. Integrated area under the curve (AUC) corresponding to the time course of SBP response to AngII for HF-fed female Ace2^fl/fl (c) or HF-fed male Ace2^fl/y (d) and Ace2^Adipo mice. Data are mean + SEM for n = 4 mice/genotype. #p < 0.05 compared to Ace2^fl/fl at each time point using repeated measures (RM) two-way ANOVA; *p < 0.05 compared to Ace2^fl/fl using t test