Sex differences in metabolic effects of angiotensin-(1-7) treatment in obese mice

Table 2 Regression analysis of insulin tolerance testing results in Figs. 2 and 3

	Estimate	SE	T-statistic	P value
Fasting Glucose
Drug (=Ang-(1-7))	19.421	11.091	1.751	0.084
Diet (=HFD)	20.288	10.511	1.930	0.058
Sex (=female)	− 15.141	11.645	− 1.300	0.198
Fasting Insulin
Drug (=Ang-(1-7))	0.291	0.530	0.549	0.585
Diet (=HFD)	2.722	0.502	5.422	0.001
Sex (=female)	− 0.707	0.556	− 1.271	0.208
Diet:Sex	− 2.120	0.628	− 3.375	0.001
AUC Glucose
Drug (=Ang-(1-7))	− 43.09	1045.98	− 0.041	0.967
Diet (=HFD)	5284.48	991.32	5.331	0.001
Sex (=female)	− 872.61	1098.21	− 0.795	0.430
Drug:Diet	− 3998.21	1224.93	− 3.264	0.002

Data were analyzed by multiple regressions with the adjusted P values obtained based on Wald tests. Results are shown for main effects of drug, diet, and sex and for interactions when reaching statistical significance (P < 0.05). SE standard error, AUC area under the curve

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