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Fig. 6 | Biology of Sex Differences

Fig. 6

From: Sex differences in metabolic effects of angiotensin-(1-7) treatment in obese mice

Fig. 6

Plasma Ang II and Ang-(1-7) concentrations. Plasma angiotensin (Ang)-(1-7) and Ang II concentrations measured in control diet- and high-fat diet (HFD)-fed male and female mice chronically treated with Ang-(1-7) versus saline (n = 7–12/group). a, b Females exhibited lower circulating Ang-(1-7) concentrations, with no significant effect of diet. As expected, chronic Ang-(1-7) infusion significantly increased plasma levels of this hormone, particularly in chow-fed male mice, as evidenced by interactions of drug infusion with diet and sex. c, d There were no main effects of diet or sex on plasma Ang II levels. Chronic Ang-(1-7) infusion produced reflexive increases in plasma Ang II levels, with no interactions with diet or sex. Data are mean ± SEM and were analyzed by multiple regression for main effects of sex (PSex), diet (PDiet), and drug (PDrug) and their pairwise interactions (PDrug:Sex, PDiet:Sex, and PDrug:Diet)

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