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Table 3 Brain regions with significantly (one tailed Z > 2.75, p < 0.005) greater mental stress-induced activation or deactivation in women (n = 53) relative to men (n = 112) with coronary artery disease as measured with [15O]H2O positron emission tomography

From: Sex differences in brain activation patterns with mental stress in patients with coronary artery disease

Voxel number Brain regions Brodmann’s area Talairach Z score
X Y Z
Greater stress activation in women than men
 22 L cerebellum   − 26 − 40 − 18 5.26
 86 L cerebellum   − 18 − 69 − 18 4.85
  L cerebellum   − 16 − 76 − 13 3.61
 42 R parietal lobe, postcentral gyrus 40 51 − 32 50 4.75
 26 R cerebellum   46 − 63 − 19 4.25
 36 R cerebellum   10 − 72 − 10 4.25
 11 R parietal lobe, postcentral gyrus 3 53 − 9 49 4.13
  R frontal lobe, precentral gyrus 6 48 − 7 54 2.82
 96 L cerebellum   − 44 − 48 − 26 3.87
  L cerebellum   − 48 − 40 − 32 3.52
 66 R posterior cingulate 31 8 − 43 39 3.74
  R parietal lobe, precuneus 7 4 − 51 38 3.54
 12 L occipital lobe, fusiform gyrus 19 − 42 − 65 − 9 3.73
 14 R frontal lobe, precentral gyrus 6 59 − 10 42 3.72
 22 R cerebellum   24 − 50 − 23 3.56
 19 R frontal lobe, superior gyrus 9 42 37 32 3.55
  R frontal lobe, middle gyrus 9 42 46 26 2.66
 33 R parietal lobe, inferior lobule 40 48 − 58 48 3.53
 68 R parietal lobe, superior lobule 7 30 − 59 53 3.51
  R parietal lobe, inferior lobule 40 38 − 52 53 3.38
 19 R cerebellum   22 − 75 − 15 3.47
 32 L temporal lobe, fusiform gyrus 37 − 50 − 61 − 17 3.44
 12 R frontal lobe, precentral gyrus 44 59 10 13 3.28
Greater stress deactivation in women than men
 23 L anterior cingulate 24 − 4 23 24 5.02
 51 R frontal lobe, superior gyrus 6 14 22 51 5.00
 95 R frontal lobe, inferior gyrus 47 24 22 − 20 4.67
  R frontal lobe, orbital gyrus 47 22 30 − 23 3.07
 64 L frontal lobe, medial gyrus 6 − 14 29 36 4.63
  L frontal lobe, superior gyrus 8 − 10 32 47 3.50
 86 R frontal lobe, inferior gyrus 47 44 27 − 8 4.53
  R frontal lobe, inferior gyrus 47 50 28 − 13 4.04
 46 L frontal lobe, superior gyrus 6 − 6 14 55 4.46
  L frontal lobe, superior gyrus 6 0 11 58 3.25
 28 L parietal lobe, supramarginal gyrus 40 − 63 − 43 27 4.39
  L temporal lobe, supramarginal gyrus 40 − 63 − 51 23 3.35
 49 L frontal lobe, inferior gyrus   − 53 18 1 4.06
 17 L parietal lobe, superior lobule 7 − 26 − 64 50 4.00
 32 R temporal lobe, middle gyrus 21 69 − 45 − 8 3.99
 37 L parietal lobe, precuneus 7 − 14 − 44 59 3.84
 26 R frontal lobe, medial gyrus 9 22 38 23 3.84
 34 L frontal lobe, medial gyrus 10 − 6 55 7 3.81
 34 R temporal lobe, middle gyrus 21 61 − 3 − 17 3.74
 11 R anterior cingulate 32 2 27 34 3.73
 26 R frontal lobe, subcallosal gyrus 34 18 7 − 12 3.68
 13 L frontal lobe, superior gyrus 8 0 28 49 3.67
 36 R frontal lobe, medial gyrus 10 10 55 17 3.55
  R frontal lobe, medial gyrus 9 2 46 18 2.82
 51 R frontal lobe, middle gyrus 11 42 42 − 19 3.54
  R frontal lobe, middle gyrus 11 38 52 − 14 3.42
 31 L parietal lobe, postcentral gyrus 5 − 30 − 44 58 3.53
 14 L frontal lobe, middle gyrus 6 − 38 12 46 3.53
 14 L frontal lobe, inferior gyrus 45 − 59 18 6 3.50
 18 L frontal lobe, precentral gyrus 4 − 44 − 18 33 3.46
 13 L frontal lobe, superior gyrus 8 − 22 16 48 3.44
 24 R frontal lobe, middle gyrus 8 30 16 41 3.33
 29 R parietal lobe, supramarginal gyrus 40 57 − 47 31 3.30
  R parietal lobe, inferior lobule 40 51 − 51 38 3.15
 11 L parietal lobe, precuneus 7 − 10 − 40 47 3.27
 12 R frontal lobe, medial gyrus 10 2 54 − 9 3.15
 15 L parietal lobe, postcentral gyrus 3 − 28 − 23 46 3.13
 11 L frontal lobe, inferior gyrus   − 40 43 3 2.99
 17 L frontal lobe, middle gyrus 11 − 38 50 − 14 2.95
 13 R parahippocampal gyrus 30 8 − 39 7 2.77
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Biology of Sex Differences

ISSN: 2042-6410

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