From: Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats
 | Females | Males | Two-way ANOVA | ||||
---|---|---|---|---|---|---|---|
Control | EtOH-exposed | Control | EtOH-exposed | P trt | P sex | P trt*sex | |
HiK | |||||||
 Contraction (mN mm−1) | 10.9 ± 0.4 | 11.4 ± 0.7 | 11.4 ± 1.1 | 10.8 ± 0.8 | NS | NS | NS |
PE | |||||||
 pEC50 | 7.03 ± 0.15 | 6.96 ± 0.12 | 7.12 ± 0.04 | 7.25 ± 0.06 | NS | NS | NS |
 Max. contraction (% HiK) | 113 ± 2 | 117 ± 2 | 111 ± 3 | 116 ± 4 | NS | NS | NS |
AngII | |||||||
 pEC50 | 8.17 ± 0.26 | 8.16 ± 0.09 | 8.47 ± 0.15 | 8.44 ± 0.17 | NS | NS | NS |
 Max. contraction (% HiK) | 21 ± 6 | 26 ± 10 | 33 ± 13 | 34 ± 13 | NS | NS | NS |
SNP | |||||||
 pEC50 | 8.07 ± 0.10 | 8.05 ± 0.07 | 7.95 ± 0.10 | 7.89 ± 0.09 | NS | NS | NS |
 Rmax (%) | 95 ± 2 | 91 ± 5 | 96 ± 3 | 97 ± 1 | NS | NS | NS |
ACh | |||||||
 pEC50 | 6.85 ± 0.23 | 6.99 ± 0.15 | 6.79 ± 0.09 | 6.97 ± 0.18 | NS | NS | NS |
 Rmax (%) | 94 ± 3 | 97 ± 1 | 89 ± 6 | 92 ± 6 | NS | NS | NS |
ACh + L-NAME + INDO | |||||||
 pEC50 | 7.18 ± 0.21 | 6.98 ± 0.24 | 7.27 ± 0.16 | 7.26 ± 0.32 | NS | NS | NS |
 Rmax (%) | 34 ± 7 | 48 ± 10 | 19 ± 3 | 21 ± 5 | NS | P = 0.04 | NS |