Fig. 1

Wild-type and Siah2KO female mice fed a high-fat diet have percent fat mass comparable to male mice, but higher levels of brown fat relative to total fat mass. a Body weight, b percent fat mass, and c fat pad weight/total fat mass were measured in the wild-type (WT) and Siah2KO female and male mice fed a defined low (LFD)- or high (HFD)-fat diet over 16 weeks. Statistical significance was determined using repeated measures ANOVA in a and b and two-tailed, unpaired t test in c, a, p < 0.05; within sex comparison between genotypes. b, p < 0.05; between sex comparison of related genotype