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Table 4 Rates of change in postoperative cognitive test scores in men vs. women stratified by APOE4 status—APOE4− carriers

From: Sex and genetic differences in postoperative cognitive dysfunction: a longitudinal cohort analysis

  Men APOE4− non-surgical (slope)
n = 177
Women APOE4− non-surgical (slope)
n = 348
Men APOE4− surgical (slope)
n = 69
Women APOE4− surgical (slope)
n = 123
Surgical-sex interaction on rate of change—Non-Carriers (p value)
Global cognitive function tests MMSE − 0.01485 − 0.01571 − 0.01948 − 0.02411 0.15
CDR-SB 0.2749 0.2654169 0.3305 0.3888 0.02
Memory-based tests Logical Memory Delayed Recall − 0.05689 − 0.05369 − 0.1959 − 0.2873 0.19
CERAD Delayed Word List − 0.03427 − 0.04447 − 0.04921 − 0.05608 0.64
Attention-based tests Digit Symbol − 0.9422 − 0.9187 − 1.297 − 1.232 0.78
SDMT − 0.03789 − 0.02705 − 0.02942 − 0.03062 0.21
Executive function tests Trails Making Test B 7.005 3.892 3.388 6.532 0.96
Animal Category Fluency − 0.4282 − 0.3635 − 0.5056 − 0.5563 0.15
  1. NS not significant, italicized p values are significant
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