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Table 2 Cohort demographics and cognitive outcomes at study entry

From: Sex and genetic differences in postoperative cognitive dysfunction: a longitudinal cohort analysis

  Non-surgical men (n = 297) Non-surgical women (n = 493) Surgical men (n = 89) Surgical women (n = 164) Sex effect
p value
Surgical effect
p value
APOE4 effect
p value
Mean age, years (SD) 78.5 (10.3) 81.5 (9.2) 78.1 (7.8) 79.4 (7.7) < 0.001 0.035 < 0.001
Mean education, years (SD) 14.8 (3.3) 13.7 (2.9) 15.9 (2.7) 14.5 (2.7) < 0.0001 < 0.001 0.72
Cumulative Illness Rating Scale (SD) 22.5 (4.3) 22.4 (3.9) 21.8 (3.7) 21.6 (3.4) 0.66 0.003 0.002
Presence of an APOE4 allele (%) 39 28 22 25 0.008 0.014
Asian 0 6 1 0
Black 6 36 6 28
Native American 1 2 0 0
Caucasian/White 285 443 82 135
Obesity (%) 66 26 65 29 < 0.0001 0.51 0.065
Diabetes (%) 10 11 13 12 1 0.68 0.003
Hypertension (%) 56 65 52 74 < 0.001 0.014 0.082
Thyroid disorder (%) 2 7 2 11 < 0.0001 0.19 0.87
MMSE 24.9 (5.8) 26.0 (5.3) 28.6 (1.4) 28.5 (1.5) 0.008 < 0.001 < 0.001
CDR-SB 1.8 (2.9) 1.4 (3.1) 0.1 (0.27) 0.1 (0.26) 0.11 < 0.001 < 0.001
Logical Memory Delayed Recall 8.3 (4.7) 9.3 (4.9) 11.6 (4.3) 11.5 (4.2) 0.19 < 0.001 0.004
CERAD Delayed Word List 4.9 (2.4) 5.7 (2.5) 6.6 (1.7) 6.8 (2.0) 0.002 < 0.001 < 0.001
Digit Symbol 32.5 (13.6) 37.2 (10.6) 40.1 (8.8) 41.7 (11.4) 0.003 < 0.001 0.073
SDMT 39.9 (11.1) 38.3 (10.3) 47.2 (14.2) 39.7 (12.6) 0.088 0.40 0.62
Trails Making Test B 141.7 (80.8) 133.0 (69.2) 90.5 (30.1) 112.5 (45.6) 0.94 0.006 0.27
Animal Category Fluency 16.9 (5.3) 15.9 (5.2) 20.6 (5.0) 17.7 (4.7) < 0.0001 < 0.001 0.30
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