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Table 2 Representative gender-specific association on X chromosome in discovery cohort

From: X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma

Marker Position Minor allele Annotation MAFmalesa ORM P M MAFfemalesa ORF P F ORI P I
Males
 rs6641142 4825493 C 299 kb 3′ of LOC101928201 0.22/0.14 1.31 2.50 × 10−5 0.20/0.19 1.078 6.05 × 10−1 1.21 2.34 × 10−1
 rs12842370 124071272 A TENM1 0.47/0.44 1.22 4.51 × 10−5 0.51/0.47 1.05 7.02 × 10−1 1.15 2.58 × 10−1
 rs6629842 24276842 C 427 kb 3′ of ZFX 0.49/0.40 1.21 1.21 × 10−4 0.47/0.50 0.87 2.17 × 10−1 1.35 1.20 × 10−2
 rs5927056 31969744 G DMD 0.22/0.3 0.81 1.17 × 10−4 0.22/0.27 0.77 4.66 × 10−2 1.04 7.62 × 10−1
 rs140712668 95192068 T 400 kb 5′ of BRDTP1 0.39/0.31 1.22 1.20 × 10−4 0.35/0.38 0.85 1.77 × 10−1 0.89 1.20 × 10−2
Females
 rs10127187 26108742 C 47Kb 3′ of MAGEB18 0.06/0.08 0.87 8.65 × 10−1 0.05/0.11 0.42 5.02 × 10−5 2.02 2.40 × 10−3
 rs10442369 44182366 A EFHC2 0.32/0.28 1.08 1.40 × 10−1 0.24/0.33 0.63 1.42 × 10−4 1.66 1.19 × 10−4
 rs6527885 19067421 A ADGRG2 0.50/0.49 1.01 8.01 × 10−1 0.47/0.42 1.56 1.67 × 10−4 1.08 7.57 × 10−2
 rs5933886 11463381 T ARHGAP6 0.19/0.27 1.05 4.10 × 10−1 0.20/0.19 0.62 4.37 × 10−4 1.66 6.25 × 10−4
 rs12847598 26558711 C 177Kb 5′ of VENTXP1 0.07/0.08 0.9 2.58 × 10−1 0.05/0.11 0.46 2.32 × 10−4 1.95 3.21 × 10−3
Gender-SNP
 rs2002686 44182139 A EFHC2 0.31/0.27 1.08 1.29 × 10−1 0.23/0.33 0.62 1.48 × 10−4 1.69 8.35 × 10−5
 rs3859959 43496280 C 20 kb 5′ of MAOA 0.39/0.45 0.88 7.88 × 10−3 0.47/0.38 1.42 2.12 × 10−3 0.63 1.22 × 10−4
 rs12834592 92782494 C 143 kb 5′ of NAP1L3 0.44/0.47 0.94 2.00 × 10−1 0.49/0.39 1.51 3.49 × 10−4 0.63 1.86 × 10−4
 rs6603446 115968398 G 374 kb 3′ of CT83 0.45/0.42 1.07 1.90 × 10−1 0.40/0.49 0.68 7.25 × 10−4 1.58 2.24 × 10−4
 rs72620283 21923327 A 20 kb 3′ of MBTPS2 0.21/0.21 0.97 6.23 × 10−1 0.24/0.16 1.68 6.01 × 10−4 0.57 4.71 × 10−4
 rs139949129 11449691 T ARHGAP6 0.17/0.15 1.06 3.99 × 10−1 0.16/0.23 0.59 3.81 × 10−4 1.74 4.72 × 10−4
  1. The association tests were conducted by using logistic regression adjusted for the first 10 principal components. ORM and PM, odds ratio and P value for single point association test in males; ORF and PF, odds ratio and P value for single point association test in females; ORI and PI, odds ratio and P value for gender-SNP interaction
  2. aMAF presents as minor allele frequency in cases/minor allele frequency in controls