Table 2 Representative gender-specific association on X chromosome in discovery cohort
From: X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma
Marker | Position | Minor allele | Annotation | MAFmalesa | ORM | P M | MAFfemalesa | ORF | P F | ORI | P I |
|---|---|---|---|---|---|---|---|---|---|---|---|
Males | |||||||||||
 rs6641142 | 4825493 | C | 299 kb 3′ of LOC101928201 | 0.22/0.14 | 1.31 | 2.50 × 10−5 | 0.20/0.19 | 1.078 | 6.05 × 10−1 | 1.21 | 2.34 × 10−1 |
 rs12842370 | 124071272 | A | TENM1 | 0.47/0.44 | 1.22 | 4.51 × 10−5 | 0.51/0.47 | 1.05 | 7.02 × 10−1 | 1.15 | 2.58 × 10−1 |
 rs6629842 | 24276842 | C | 427 kb 3′ of ZFX | 0.49/0.40 | 1.21 | 1.21 × 10−4 | 0.47/0.50 | 0.87 | 2.17 × 10−1 | 1.35 | 1.20 × 10−2 |
 rs5927056 | 31969744 | G | DMD | 0.22/0.3 | 0.81 | 1.17 × 10−4 | 0.22/0.27 | 0.77 | 4.66 × 10−2 | 1.04 | 7.62 × 10−1 |
 rs140712668 | 95192068 | T | 400 kb 5′ of BRDTP1 | 0.39/0.31 | 1.22 | 1.20 × 10−4 | 0.35/0.38 | 0.85 | 1.77 × 10−1 | 0.89 | 1.20 × 10−2 |
Females | |||||||||||
 rs10127187 | 26108742 | C | 47Kb 3′ of MAGEB18 | 0.06/0.08 | 0.87 | 8.65 × 10−1 | 0.05/0.11 | 0.42 | 5.02 × 10−5 | 2.02 | 2.40 × 10−3 |
 rs10442369 | 44182366 | A | EFHC2 | 0.32/0.28 | 1.08 | 1.40 × 10−1 | 0.24/0.33 | 0.63 | 1.42 × 10−4 | 1.66 | 1.19 × 10−4 |
 rs6527885 | 19067421 | A | ADGRG2 | 0.50/0.49 | 1.01 | 8.01 × 10−1 | 0.47/0.42 | 1.56 | 1.67 × 10−4 | 1.08 | 7.57 × 10−2 |
 rs5933886 | 11463381 | T | ARHGAP6 | 0.19/0.27 | 1.05 | 4.10 × 10−1 | 0.20/0.19 | 0.62 | 4.37 × 10−4 | 1.66 | 6.25 × 10−4 |
 rs12847598 | 26558711 | C | 177Kb 5′ of VENTXP1 | 0.07/0.08 | 0.9 | 2.58 × 10−1 | 0.05/0.11 | 0.46 | 2.32 × 10−4 | 1.95 | 3.21 × 10−3 |
Gender-SNP | |||||||||||
 rs2002686 | 44182139 | A | EFHC2 | 0.31/0.27 | 1.08 | 1.29 × 10−1 | 0.23/0.33 | 0.62 | 1.48 × 10−4 | 1.69 | 8.35 × 10−5 |
 rs3859959 | 43496280 | C | 20 kb 5′ of MAOA | 0.39/0.45 | 0.88 | 7.88 × 10−3 | 0.47/0.38 | 1.42 | 2.12 × 10−3 | 0.63 | 1.22 × 10−4 |
 rs12834592 | 92782494 | C | 143 kb 5′ of NAP1L3 | 0.44/0.47 | 0.94 | 2.00 × 10−1 | 0.49/0.39 | 1.51 | 3.49 × 10−4 | 0.63 | 1.86 × 10−4 |
 rs6603446 | 115968398 | G | 374 kb 3′ of CT83 | 0.45/0.42 | 1.07 | 1.90 × 10−1 | 0.40/0.49 | 0.68 | 7.25 × 10−4 | 1.58 | 2.24 × 10−4 |
 rs72620283 | 21923327 | A | 20 kb 3′ of MBTPS2 | 0.21/0.21 | 0.97 | 6.23 × 10−1 | 0.24/0.16 | 1.68 | 6.01 × 10−4 | 0.57 | 4.71 × 10−4 |
 rs139949129 | 11449691 | T | ARHGAP6 | 0.17/0.15 | 1.06 | 3.99 × 10−1 | 0.16/0.23 | 0.59 | 3.81 × 10−4 | 1.74 | 4.72 × 10−4 |