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Table 1 Body weight, body adiposity, lean body mass, and serum analysis

From: Sex-specific lipid molecular signatures in obesity-associated metabolic dysfunctions revealed by lipidomic characterization in ob/ob mouse

  F M   P values
Final BW (g) 47.6 ± 1.1 49.8 ± 0.7   ns
BW gain (g) 7.9 ± 0.8 8.1 ± 0.8   ns
Total body fat mass (g) 28.3 ± 0.5 26.1 ± 0.6 * P < 0.05
Lean mass (g) 19.0 ± 0.4 20.3 ± 0.4 * P < 0.05
% fat mass 57 ± 1 54 ± 1 ** P < 0.01
% lean mass 38 ± 1 42 ± 1 ** P < 0.01
Cumulative food intake (g) 1217 ± 1 1255 ± 1   ns
Food efficiency (g/ΔBW) 154 ± 12 155 ± 10   ns
Liver (%TF) 8.5 ± 0.3 11.5 ± 0.2 *** P < 0.001
VAT (%TF) 27.1 ± 0.5 29.3 ± 0.6 * P < 0.05
SAT (%TF) 20.8 ± 0.3 17.0 ± 0.9 ** P < 0.01
SAT/VAT 0.77 ± 0.02 0.58 ± 0.03 *** P < 0.001
Serum analysis
 Fasted glucose (mM) 10.7 ± 0.3 9.1 ± 0.4   ns
 Fasted insulin (ng/ml) 2.1 ± 0.2 3.4 ± 0.4 * P < 0.05
 HOMA-IR 0.8 ± 0.1 1.3 ± 0.1 ** P < 0.01
 Triglycerides (mM) 0.20 ± 0.01 0.65 ± 0.09 ** P < 0.01
 Adiponectin (pg/ml) 5740 ± 361 4985 ± 212   P = 0.06
 Resistin (pg/ml) 22.6 ± 2.9 44.6 ± 2.4 ** P < 0.01
 FGF21 (pg/ml) 5380 ± 189 3583 ± 444 ** P < 0.01
 TNFα (pg/ml) 465 ± 72 374 ± 55   ns
 IL1β (pg/ml) 88 ± 17 94 ± 16   ns
 IL6 (pg/ml) 29 ± 7 21 ± 3   ns
 IL10 (pg/ml) 437 ± 83 239 ± 28 * P = 0.01
  1. Data are presented as mean ± sem, n = 7–10. Differences between sexes were determined by two-tailed student’s t test with statistical significance determined using the Holm-Sidak method, with alpha = 5.000%. Each row was analyzed individually, without assuming a consistent SD. *, P < 0.05, **, P < 0.01, ***, P < 0.001 M vs F were considered significant. ns = not significant. M male, F female, TF total fat, VAT visceral fat (comprises the gAT, omental and retroperitoneal adipose depots), SAT subcutaneous adipose tissue (comprises the iAT and dorsal adipose depots), HOMA-IR homeostatic model assessment-insulin resistance, FGF21 fibroblast growth factor 21, TNF tumor necrosis factor and IL interleukin