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Table 2 Proteins identified from human carotid atheroma which discriminate samples by sex, men or women, in accordance with a significant variable influence on projection (VIP ≥ 1.2) in multivariate analysis

From: Proteomics and multivariate modelling reveal sex-specific alterations in distinct regions of human carotid atheroma

Protein name Accession number Biological function VIP Average LFQ (E + 06) Fold change men /women P value Bonferroni adjusted P value
Men mean (SD) Women mean (SD)
Cofilin-1 P23528 Actin organisation 1.29 12.4 (12.3) 7.9 (7.2) 1.56 0.270
Transgelin-2 P37802 Actin organisation 1.49 26.8 (28.8) 16.8 (17.1) 1.60 0.225
Coagulation factor XII P00748 Blood coagulation 1.51 12.4 (12.3) 7.9 (7.2) 1.56 < 0.001* 0.029*
Antithrombin-III P01008 Blood coagulation 1.91 14.1 (5.4) 23.3 (10.8) 0.61 < 0.001* 0.018*
Plasma protease C1 inhibitor P05155 Blood coagulation 1.30 8.3 (6.5) 10.5 (6.4) 0.79 0.138
Heparin cofactor 2 P05546 Blood coagulation 1.34 3.9 (3.1) 6.2 (4.2) 0.63 0.014 0.635
Protein S100-A11 P31949 Cell cycle 1.26 7.9 (5.8) 6.6 (5.9) 1.20 0.266
Ubiquitin-60S ribosomal protein L40 P62987 Cell cycle 1.86 5.6 (3.1) 3.9 (2.1) 1.42 0.045* 1.950
Annexin A5 P08758 Cell death 1.28 28.3 (18.5) 23.2 (18.7) 1.22 0.163
14-3-3 protein beta/alpha P31946 Cell death 1.43 5.3 (3.5) 4.0 (1.8) 1.33 0.379
Complement factor B P00751 Complement activation 1.66 9.7 (4.2) 14.7 (7.9) 0.69 0.025* 1.111
Ig kappa chain V-II region TEW P01617 Complement activation 1.59 5.7 (2.6) 4.0 (1.8) 1.43 0.009* 0.408
CD59 glycoprotein P13987 Complement activation 1.27 1.9 (1.2) 2.5 (1.9) 0.76 0.237
Haemoglobin subunit beta P68871 Haemoglobin/haptoglobin 1.44 1495 (1426) 1049 (1176) 1.43 0.219
Haemoglobin subunit alpha P69905 Haemoglobin/haptoglobin 1.62 510 (628) 318 (415) 1.61 0.164
Haptoglobin P00738 Haemoglobin/haptoglobin 1.28 117 (151) 161 (170) 0.73 0.054
Alpha-1-antichymotrypsin P01011 Inflammatory response 1.63 17.4 (11.1) 29.1 (20.3) 0.60 0.034* 1.453
Annexin A1 P04083 Inflammatory response 1.48 28.3 (13.7) 22.0 (11.5) 1.28 0.065
Phospholipase A2, membrane-associated P14555 Inflammatory response 1.47 2.2 (2.0) 1.1 (1.2) 1.90 0.034* 1.478
Alpha-1-acid glycoprotein P19652 Inflammatory response 1.43 3.9 (2.0) 7.3 (4.3) 0.53 0.002* 0.107
Lysozyme C P61626 Inflammatory response 1.72 74.9 (30.0) 10.2 (9.4) 7.38 0.039* 1.686
Protein S100-A6 P06703 Ion transport 1.44 13.2 (15.7) 8.3 (11.9) 1.59 0.093
Translationally-controlled tumour protein P13693 Ion transport 1.35 1.5 (1.0) 1.0 (0.5) 1.51 0.070
LIM and SH3 domain protein 1 Q14847 Ion transport 1.23 4.6 (3.0) 3.4 (3.0) 1.37 0.109
Serotransferrin P02787 Iron homeostasis 1.43 179 (61.3) 264 (142) 0.68 0.013* 0.559
Haemopexin P02790 Iron homeostasis 1.49 62.4 (33.7) 104 (73.7) 0.60 0.030* 1.28
Ferritin heavy chain P02794 Iron homeostasis 1.21 54.4 (42.5) 42.9 (38.4) 1.27 0.183
Alcohol dehydrogenase 1B P00325 Metabolism 1.20 15.3 (16.6) 13.0 (26.5) 1.17 0.136
Alpha-enolase P06733 Metabolism 1.30 29.3 (10.1) 23.7 (12.0) 1.23 0.062
Aminopeptidase N P15144 Metabolism 1.41 1.5 (1.1) 2.9 (3.7) 0.53 0.053
Inter-alpha-trypsin inhibitor heavy chain H1 P19827 Peptidase activity (negative) 1.62 11.8 (7.3) 18.8 (17.6) 0.63 0.132
Phosphatidylethanolamine-binding protein 1 P30086 Peptidase activity (negative) 1.76 6.4 (4.4) 3.7 (2.7) 1.71 0.007* 0.286
Glutathione S-transferase P P09211 Response to ROS 1.58 5.9 (3.2) 4.5 (3.1) 1.31 0.053
Glutathione S-transferase omega-1 P78417 Response to ROS 1.20 2.4 (2.4) 3.2 (1.7) 0.75 0.009* 0.420
Peroxiredoxin-1 Q06830 Response to ROS 1.42 12.3 (5.8) 10.0 (6.2) 1.23 0.076
SH3 domain-binding glutamic acid-rich-like protein O75368 Signal transduction 1.33 4.8 (6.0) 3.0 (3.0) 1.61 0.178
Ribonuclease 4 P34096 Transcription 1.23 4.1 (4.0) 2.7 (1.5) 1.56 0.100
Heterogeneous nuclear ribonucleoprotein K P61978 Transcription 1.24 2.2 (1.2) 1.5 (0.6) 1.45 0.030* 1.304
Retinol-binding protein 4 P02753 Transport 1.20 1.8 (0.8) 2.3 (0.9) 0.79 0.051
Corticosteroid-binding globulin P08185 Transport 1.41 0.9 (0.2) 1.4 (0.6) 0.68 0.006* 0.275
Zinc-alpha-2-glycoprotein P25311 Transport 1.63 3.1 (1.1) 4.5 (2.3) 0.70 0.041* 1.752
Afamin P43652 Transport 2.34 2.0 (0.7) 4.4 (2.4) 0.46 < 0.0001* < 0.001*
Alpha-1B-glycoprotein P04217 Unknown 1.42 11.0 (4.7) 17.6 (9.1) 0.63 0.002* 0.077
  1. *significance p < 0.05