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Fig. 4 | Biology of Sex Differences

Fig. 4

From: Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

Fig. 4

Bayesian gene network representations of NAFLD pathways and their key driver genes. a Liver Bayesian subnetwork comprised of shared liver NAFLD supersets between sexes and their top key drivers. b Adipose tissue Bayesian subnetwork comprised of shared adipose NAFLD supersets between sexes and their top key drivers. Female-specific c liver Bayesian subnetworks and d adipose tissue Bayesian subnetworks and their corresponding top key drivers. Male-specific e liver Bayesian subnetworks and f adipose tissue Bayesian subnetworks and their corresponding top key drivers. Key driver genes are shown with larger node sizes, human GWAS candidate genes are represented in hexagon shapes, and the rest of the genes are represented by smaller node sizes. Each NAFLD-associated superset is indicated with a distinct color in each network. Network genes that are not members of the NAFLD supersets are represented in gray. See also Additional file 4

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