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Table 1 Summary of key results from gonadectomized Mito-Ob and wild-type mice relative to sham-operated control mice

From: Gonadectomy in Mito-Ob mice revealed a sex-dimorphic relationship between prohibitin and sex steroids in adipose tissue biology and glucose homeostasis

Experimental groups Wild-type Mito-Ob
Sham Gonadx Sham Gonadx
- Similar food intake - Similar food intake - Similar food intake - Similar food intake
- Increased body weight - Reduced body weight
- No apparent change in SAT and VAT - Reduced SAT and VAT weights
- Reduced adipocyte size in VAT - No significant difference in VAT adipocyte size
- Higher cumulative number of larger adipocytes - Higher cumulative number of smaller adipocytes
- Improved glucose disposal - Improved glucose disposal
- Similar food intake - Similar food intake - Similar food intake - Similar food intake
- Increased body weight - Reduced body weight
- Increased SAT and VAT weights - Reduced SAT and VAT weights
- Increase in adipocyte size - Reduced adipocyte size in both VAT and SAT
- Higher cumulative number of larger adipocytes - Higher cumulative number of smaller adipocytes
- Differential effects on adipogenic and mitochondrial biogenesis markers with/without sex steroids - Differential effects on adipogenic and mitochondrial biogenesis markers with/without sex steroids
- No significant difference in glucose disposal - Slightly better glucose disposal
  1. Gonadx gonadectomized, SAT subcutaneous adipose tissue, VAT visceral adipose tissue