Table 1 Summary of key results from gonadectomized Mito-Ob and wild-type mice relative to sham-operated control mice
Experimental groups | Wild-type | Mito-Ob | ||
|---|---|---|---|---|
Sham | Gonadx | Sham | Gonadx | |
♂ | - Similar food intake | - Similar food intake | - Similar food intake | - Similar food intake |
- Increased body weight | - Reduced body weight | |||
- No apparent change in SAT and VAT | - Reduced SAT and VAT weights | |||
- Reduced adipocyte size in VAT | - No significant difference in VAT adipocyte size | |||
- Higher cumulative number of larger adipocytes | - Higher cumulative number of smaller adipocytes | |||
- Improved glucose disposal | - Improved glucose disposal | |||
♀ | - Similar food intake | - Similar food intake | - Similar food intake | - Similar food intake |
- Increased body weight | - Reduced body weight | |||
- Increased SAT and VAT weights | - Reduced SAT and VAT weights | |||
- Increase in adipocyte size | - Reduced adipocyte size in both VAT and SAT | |||
- Higher cumulative number of larger adipocytes | - Higher cumulative number of smaller adipocytes | |||
- Differential effects on adipogenic and mitochondrial biogenesis markers with/without sex steroids | - Differential effects on adipogenic and mitochondrial biogenesis markers with/without sex steroids | |||
- No significant difference in glucose disposal | - Slightly better glucose disposal | |||