Fig. 3

a, c Representative histomicrographs showing hematoxylin and eosin stained VAT and SAT from gonadectomized (Ovx or Orx) and sham-operated (Sham) male and female Mito-Ob and wild-type mice (40×). b, d Respective histograms showing quantification of adipocytes area. Data are presented as mean ± SEM (n = 8). *p < 0.05 represent significant differences between Ovx mice and sham control. No significant difference was found between sham-operated and gonadectomized male and female wild-type mice. Scale bars = 20 μm. Ovx—ovariectomy; Orx——orchiectomy; SAT—subcutaneous adipose tissue; VAT—visceral adipose tissue