Table 4 IPA summary of females exposed to ozone in the non-proestrus and proestrus stages
From: Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation
Non-proestrus | Proestrus | ||||
|---|---|---|---|---|---|
A. Genes targeted by differentially expressed miRNAs | |||||
CAMK2N1 CARS CYP24A1 DBF4 HMGN2 KMT5A LRRC17 MDH2 MIS18A | PAFAH1B2 PDE4B PDE7A PGM3 PNP REV1 RPS19BP1 RRAD SEC62 | SEC23A SNX5 SYT4 THAP12 TMED7 TNFAIP2 TNFRSF10C TP53 UBE2V2 ZNF420 | ABCB9 APOO ARHGEF38 AVEN CASP3 CCNJ CMTR2 CNMD DSCR8 | FGD4 FRMD4B GPR137B HMBS METAP1 MITF MYC RGMB SLC14A1 | SLC25A27 SLC38A1 TMCC1 TRIM71 XKR8 ZCCHC11 ZIM3 ZNF181 |
B. Differences in top diseases and biofunctions | |||||
Diseases and disorders | P value | Diseases and disorders | P value | ||
Inflammatory disease | 3.84E−02 to 3.84E−05 | Organismal injury and abnormalities | 4.96E−02 to 2.77E−14 | ||
Inflammatory response | 3.84E−02 to 3.84E−05 | Reproductive system disease | 2.15E−02 to 2.77E−14 | ||
Organismal injury and abnormalities | 4.17E−02 to 4.17E−05 | Cancer | 4.96E−02 to 1.27E−10 | ||
C. Top molecular and cellular functions | |||||
Molecular and cellular Functions | P value | Molecular and cellular functions | P value | ||
Cellular development | 2.05E−02 to 5.26E−07 | Cellular movement | 3.77E−02 to 4.47E−07 | ||
Cellular compromise | 3.75E−04 to 3.75E−04 | Cellular death and survival | 4.91E−02 to 5.61E−06 | ||
Cell cycle | 2.62E−03 to 2.62E−03 | Cellular development | 4.97E−02 to 1.38E−06 | ||
D. Top physiological system development and function | |||||
Development and function | P value | Development and function | P value | ||
Organismal development | 4.17E−02 to 1.31E−03 | Embryonic development | 3.30E−02 to 2.12E−05 | ||
Embryonic development | 1.29E−02 to 1.29E−02 | Connective tissue development and function | 1.79E−02 to 6.10E−05 | ||
Connective tissue development and function | 1.93E−02 to 1.93E−02 | Tissue morphology | 7.88E−05 to 7.88E−05 | ||
E Top associated network functions | |||||
Associated network functions | Score | Associated network functions | Score | ||
Cellular development, inflammatory disease, inflammatory response | 6 | Organismal injury and abnormalities, reproductive system disease, cancer | 19 | ||