Fig. 5

Protective effect of SAHA on NIHL—separated by sex. Threshold shifts were compared between SAHA- and vehicle-treated males (left) and females (right) at 24 h (a) and 15 days (b) post-noise exposure. The dots indicate individual ear threshold shifts, the upper and lower whiskers indicate the maximum and minimum shifts, respectively. a CTS values for males (left) and females (right). Male mice are protected only at 24 kHz (***p < 0.001) and female mice only at 16 kHz (*p < 0.05). b PTS values for males (left) and females (right). Females remain protected at 16 kHz (** p < 0.01) and males remain protected at 24 kHz (**p < 0.01)