Fig. 1

Effect of sex and the sex chromosome complement on ZPBP2 methylation levels. a Methylation levels of 10 CGs located within the ZPBP2 promoter region in fibroblast cell lines from 46,XX females, 46,XY males, 45,X females, 46,XY females, and 46,XX males. b Results of linear regression analysis showing means and 95% confidence intervals of the first principal component, averaged over the two sexes. The differences are interpretable as changes in percent methylation, although the exact values are intercept adjusted. Left: one X chromosome; right: 2 or more X chromosomes. Within each panel, SRY is denoted as absent or present