Skip to main content

Table 7 Chromosome X-linked genes with Y homologs

From: Sex differences in the late first trimester human placenta transcriptome

Chr X gene

XCI

▲ F

Chr X location

Gene descriptions

Chr Y gene

▲ M

Chr Y location

NLGN4X

E

 

p22.33

Neuroligin 4

NLGN4Y

A

q11.221

TBL1X

E

 

p22.3

Tranducin β-like 1

TBL1Y

A

p11.2

AMELX

 

p22.31-p22.1

Amelogenin

AMELY

A

p11.2

TMSB4X

 

q21.3-q22

Thymosin β4

TMSB4Y

A

q11.221

TXLNG

E

A

p22.2

Taxilin γ

TXLNGY

P

q11.222-q11.223

EIF1AX

E

P, A

p22.12

Eukaryotic translation initiation factor 1A

EIF1AY

P, A

q11.223

ZFX

E

P, A

p21.3

Zinc finger protein

ZFY

P, A

p11.2

USP9X

E

 

p11.4

Ubiquitin specific peptidase 9

USP9Y

P, A

q11.221

DDX3X

E

P, A

p11.3-p11.23

DEAD-box helicase 3

DDX3Y

P, A

q11.221

KDM6A

E

P, A

p11.2

Lysine demethylase

UTY

P, A

q11.221

TSPYL2

S

 

p11.2

Testis-specific protein Y-encoded (like 2)

TSPY1

 

p11.2

KDM5C

E

P, A

p11.22-p11.21

Lysine demethylase

KDM5D

P, A

q11.223

RPS4X

E

P, A

q13.1

Ribosomal protein S4

RPS4Y1

P, A

p11.2

TGIF2LX

 

q21.31

TGFβ-induced factor homeobox2-like

TGIF2LY

 

p11.2

PCDH11X

E

 

q21.3

Protocadherin 11

PCDH11Y

P, A

p11.2

XKRX

S

 

q22.1

XK, Kell blood group complex subunit-related

XKRY

 

q11.222

RBMX

S

 

q26.3

RNA binding motif

RBMY

 

q11.223

SOX3

S

 

q27.1

SRY-box 3/sex determining region Y

SRY

A

p11.2

HSFX1

 

q28

Heat shock transcriptional factor family

HSFY1

 

q11.222

  1. Table of all X/Y homologs (excluding Y pseudogenes), sorted by location of X-linked genes. X chromosome inactivation (XCI) status is indicated as S (silenced/inactivated), E (escapes inactivation), or “–” if unstudied, as reviewed in Balaton et al. [42]. Sexually dimorphic expression is noted when genes are upregulated in first trimester placenta (“P”, this study) and adult postmortem tissue (“A”, Mele et al. 2015) [84]. The X genes listed are located within non-PAR regions. ▲ F = upregulated in females. ▲ M = upregulated in males