Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury

Table 2 I/R-induced changes in gene expression in female forepaw muscles and C7/C8/T1 DRGs relative to naïves

Gene	DRG expression	Gene	Muscle expression
GFRα3	4.5 ± 24%	Artemin	− 38.1 ± 43%
IL6R	− 20.8 ± 46%	GDNF	42.5 ± 26%
P2X4	108.3 ± 15% *	IL-1β	− 7.6 ± 62%
P2Y1	− 6.3 ± 22%	IL-6	− 44.3 ± 53%
TNFαR	− 20.7 ± 45%	MCP-1	53.4 ± 75%
		NGF	− 14.6 ± 15%
		NT-3	− 10.5 ± 25%
		TNFα	− 2.5 ± 29%

Values indicate percentage change relative to sex- and age-matched naïve controls ± error of the difference in means (n = 6–11 per condition). *P < .05 vs. naïve obtained via Mann-Whitney Rank-Sum tests for each gene on raw sample ∆Cts, followed by the false discovery rate multiple comparisons correction within each tissue type

ISSN: 2042-6410