Sex influences eQTL effects of SLE and Sjögren’s syndrome-associated genetic polymorphisms

Table 3 SLE- and/or pSS-associated SNPs displaying differential eQTL effects in females compared to males

Chr	SNP	Reported gene(s) associated with SLE/pSS	eQTL Gene	Probe ID	Intercept	P SNP	P Sex	P SNP × Sex	β value SNP × Sex	FDR SNP × Sex
4	rs4637409	BANK1	SLC39A8	ILMN_1695316	8.13 × 10⁻³	0.016	1.20 × 10⁻⁴	2.10 × 10⁻⁴	0.66	7.90 × 10⁻³
5	rs10036748	TNIP1	CD74	ILMN_2379644	0	0.025	0.638	2.40 × 10⁻³	− 0.55	0.019
3	rs6445975	PXK	PXK	ILMN_1815063	1.34 × 10–²⁶¹	0.261	0.020	6.00 × 10⁻³	− 0.54	0.022
8	rs922483	BLK/FAM167A	CTSB	ILMN_1696360	2.85 × 10⁻³⁰⁵	0.104	0.257	6.90 × 10⁻³	0.51	0.028
8	rs13277113	BLK/FAM167A	CTSB	ILMN_1696360	1.26 × 10⁻²³²	0.068	5.00 × 10⁻³	8.60 × 10⁻³	0.50	0.029
11	rs4938573	CXCR5	ARCN1	ILMN_1699703	0.065	0.099	0.014	0.029	0.46	0.042
1	rs12753665	NCF2	DHX9	ILMN_1690965	0.442	0.126	0.158	0.013	− 0.45	0.044

Chr chromosome, SNP single nucleotide polymorphism, eQTL expression quantitative locus, P p value, β value regression coefficient, FDR false discovery rate

ISSN: 2042-6410