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Fig. 2 | Biology of Sex Differences

Fig. 2

From: Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy

Fig. 2

Development of pulmonary vascular remodeling and pulmonary fibrosis in middle-aged female ApoE-deficient mice. a Immunofluorescence images showing α-smooth muscle actin stained pulmonary arterioles in young and middle-aged female ApoE-deficient mice. b Quantification of arteriolar wall thickness for vessels less than 50 μm in young (n = 3) and MA (n = 3) ApoE-difiecent mice. *p < 0.05 vs. young female (t test). Expressed as mean ± SEM. c Masson trichrome stained lung sections showing pulmonary fibrosis (blue) in young female and middle-aged female ApoE-deficient mice. d Quantification of pulmonary fibrosis in young (n = 5) and MA (n = 4) ApoE-deficient mice. *p < 0.05 vs. young female (t test). Values are expressed as mean ± SEM

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