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Table 6 Effects of age (breakpoint >55 years) on ACE, ACE2, NEP, APN, and APA serum activities in women and men

From: Sex differences in the aging pattern of renin–angiotensin system serum peptidases

   <55 years ≥ 55 years Mann–Whitney U
Median IQR N Median IQR N Z P value
WOMEN ACE 820.3 249.77 28 815.9 272.13 30 −0.731 0.465
ACE2 61.71 16.69 28 71.11 16.22 30 −2.169 0.030
NEP 15474 1187.55 28 15703 1812.15 30 −0.965 0.335
APN 9931 5046.74 28 10238 6688.67 30 −0.747 0.455
APA 4304 1225.79 28 4361 1240.15 30 −0.327 0.744
MEN ACE 841.4 281.02 31 744.4 201.43 29 −1.960 0.049
ACE2 59.75 23.57 31 70.05 30.92 29 −1.007 0.313
NEP 16203 2030.32 31 15344 1668.93 29 −1.013 0.311
APN 11517 6916.75 31 9973 4001.23 29 −1.620 0.105
APA 4281 1633.4 31 3820 623.97 29 −1.856 0.063
  1. Note: ACE angiotensin-converting enzyme, ACE2 angiotensin-converting enzyme-2, NEP neutral endopeptidase, APN aminopeptidase N, APA aminopeptidase A