Fig. 7
From: Sex and age differences in the expression of liver microRNAs during the life span of F344 rats
Histopathological assessment of sex-biased hepatic lesions. Liver sections (hematoxylin and eosin stained) from male and female rats at 52, 78, and 104Â weeks of age were analyzed for the presence and/or severity of basophilic foci, hyperplasia of the bile duct, and vacuolization of cytoplasm in hepatocytes. Representative images are shown of (a) female-biased basophilic focus from a 104-week-old female rat and (b) normal liver from a similar area of a 104-week-old male rat; (c) male-biased hyperplasia of the bile duct (minimal) from a 52-week-old male rat and (d) normal liver from a similar area of a 52-week-old female rat; (e) male-biased vacuolization of cytoplasm (mild) in hepatocytes from a 52-week-old male rat and (f) normal liver from a similar area of a 52-week-old female rat. Arrows point to histopathological features