Table 1 Real-time QPCR validation of genes using hepatic samples in cohort 1

ACOX1

Rn01460628_m1

100 ± 7^a

75 ± 5^b

91 ± 3

94 ± 7

p (surgery × sex) < 0.05

CD36

Rn01442639_m1

100 ± 10^a

49 ± 6^b

2 ± 1^c

4 ± 1^c

p (surgery × sex) < 0.001

CPT1A

Rn00580702_m1

100 ± 9

72 ± 11

90 ± 6

79 ± 12

NS

DGAT2

Rn00584870_m1

100 ± 6^a

73 ± 6^b

54 ± 4^b

53.1 ± 4^b

p (surgery × sex) < 0.05

FASN

Rn00569117_m1

100 ± 12

70 ± 11

17 ± 5

14 ± 2

p (sex) < 0.001

LDLR

Rn00598442_m1

100 ± 8^a

64 ± 5^c

29 ± 3^b

31 ± 3^b

p (surgery × sex) < 0.01;

MGAT

Rn00585985_s1

100 ± 4

82 ± 6

68 ± 5

67 ± 6

p (sex) < 0.001

PGC1

Rn00590984_m1

100 ± 12

104 ± 12

35 ± 3

68 ± 7

p (sex) < 0.001

PPARα

Rn00566193_m1

100 ± 9

59 ± 8

106 ± 10

102 ± 11

p (sex) < 0.05, p (surgery) < 0.05,

PPARγ

Rn00440945_m1

100 ± 13

67 ± 10

85 ± 13

75 ± 11

p(surgery) < 0.05

SREBP

Rn01495769_m1

100 ± 6

68 ± 7

70 ± 10

58 ± 5

p (surgery) < 0.05, p (sex) < 0.01

ACAT2

Rn01759928_g1

100 ± 11^a

66 ± 7^b

20 ± 1^c

21 ± 3^c

p (surgery × sex) < 0.05;

CYP7a1

Rn00564065_m1

100 ± 24

85 ± 11

40 ± 7

44 ± 15

p (sex) < 0.001

MTTP

Rn01522970_m1

100 ± 7^a

64 ± 5^b

35 ± 2^c

37 ± 3^c

p (surgery × sex) < 0.001

LRH1

Rn00572649_m1

100 ± 15^a

57 ± 5^b

91 ± 7^a

92 ± 6^a

p (surgery × sex) < 0.001

Erα

Rn00433142_m1

100 ± 6^a

75 ± 5^b

81 ± 4^b

76 ± 5^b

p (surgery × sex) < 0.05

FGFR1

Rn00577234_m1

100 ± 10

106 ± 6

88 ± 5

116 ± 8

p (surgery) < 0.05

FXR

Rn00572658_m1

100 ± 7^a

59 ± 8^b

74 ± 6^b

64 ± 5^b

p (surgery × sex) < 0.05

G6PC

Rn01529640_g1

100 ± 4

80 ± 4

106 ± 6

93 ± 7

P(surgery) < 0.01

PCK1

Rn01529009_g1

100 ± 8

92 ± 12

158 ± 13

185 ± 16

P(sex) < 0.001