Fig. 9
From: Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice
Sex-dependent alteration of cardiac cytochrome CYP gene expression by doxorubicin. Doxorubicin causes male-specific induction of Cyp1b1 gene expression. Cyp1b1 enzyme is known to generate cardiotoxic metabolites such as mid-chain hydroxyeicosatetraenoic acids (HETEs) and/or 6β-hydroxytestosterone. On the other hand, DOX causes female-specific induction of Cyp2c29 and Cyp2e1 gene expression. Cyp2c29 and Cyp2e1 enzymes are known to generate cardioprotective metabolites such as epoxyeicosatrienoic acids (EETs) and 19-hydroxyeicosatetraenoic acid (19-HETE)