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Table 6 Mouse and human Y genes and X gametologs

From: A primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissues

Class

Mouse

Human

Y gene

Copy no.

X gene

Xi?

Copy no.

Y gene

X gene

Xi?

Ancestral S1

Sry

1

Sox3

Yes

1

SRY

SOX3

Yes

Rbmy

30

Rbmx

Yes

1

RBMY

RBMX

Yes

  

[Aut.]

  

HSFY

HSFX

 
  

Rps4

Yes

1

RPS4Y

RPS4X

No

Ancestral S2

Uba1y

1

Uba1

Yes

1

 

UBA1

No

Kdm5d

1

Kdm5c

No

 

KDM5D

KDM5C

No

[Tspy1ps]

 

Tspyl2

Yes

 

TSPY1

TSPX

Yes

Ancestral S3

Zfy1,2

2

Zfx

Yes

1

ZFY

ZFX

No

Uty

1

Kdm6a

No

1

UTY

KDM6A

No

Usp9y

1

Usp9x

Yes

1

USP9Y

USP9X

No

Ddx3y

1

Ddx3x

No

1

DDX3Y

DDX3X

No

Eif2s3y

1

Eif2s3x

No

1

Notea

EIF2S3X

No

  

Amelx

?

1

AMELY b

AMELX

?

Notec

 

Eif1ax

Yes

 

EIF1AY

EIF1AX

No

  

Tmsb4

?

 

TMSB4Y

TMSB4X

No

  

Txlng

?

 

TXLNGY

CYorf15

No

Ancestral S4/5

  

Tbl1x

Yes

 

TBL1Y

TBL1X

No

  

[Aut.?]

  

NLGN4Y

NLGN4X

No

  

[Aut.?]

  

PRKY

PRKX

No

Acquiredd

H2al2y

2

H2al2x

 

14

   

Prssly

1

      

Teyorf1

1

      

Rbm31y

2

Rbm31x

 

1

   

Sly

126

Slx,Slxl1

 

39

   

Ssty1,2

306

Sstx

 

11

   

Srsy

197

Srsx

 

14

   
  1. Based on information from [1922]
  2. Aut. autosomal
  3. a EIF2S3Y function replaced by an autosomally located EIF2S3X retrogene [127]
  4. bAncestral S4 in [19]
  5. c Eif1ay function replaced by an autosomally located Eif1ay retrogene [127]
  6. dMouse data only