Table 1 Expression of genes in female BMMCs relative to male BMMCs, involved in forming immune mediators stored in mast cell granules
Gene name | Gene symbol | Comments | Statistics | |
|---|---|---|---|---|
Log2 fold change | q value | |||
Tumor necrosis factor | Tnf | Proinflammatory cytokine stored in preformed mast cell granules (Gordon & Galli 1990 [81]) | 3.48 | 0.00016 |
Mast cell protease 1 | Mcpt1 | B-chymase involved in maintaining granule structure (Wastling 1998 [82]) and inflammation at mucosal sites [41] | 2.70 | 0.015 |
Mast cell protease 2 | Mcpt2 | Enzymatically inactive chymase without known function (Caughley 2011 [83]) | 0.64 | 0.00016 |
Mast cell protease 4 | Mcpt4 | Functional equivalent to human mast cell chymase (Caughley 2015 [43]) | 0.39 | 0.037 |
Mast cell protease 8 | Mcpt8 | Serine protease more closely related to granzymes and cathepsin G than chymases (Lutzelschwab 1998 [84]) | 1.71 | 0.00016 |
Tryptase beta 2 | Tpsb2 | Serine protease important for pathology in a variety of inflammatory conditions (Payne 2004 [85]) | −1.35 | 0.00016 |
Cathepsin B | Ctsb | Cysteine protease that processes protryptase to mature tryptase (Le 2011a [86]) | 0.31 | 0.015 |
Cathepsin C | Ctsc | Cysteine protease that is an upstream activator of tryptases, chymases, and cathepsin G (Caughley 2015 [43]) | 0.99 | 0.00016 |
Cathepsin G | Ctsg | Serine protease with tryptic and chymotryptic activity (Caughley 2007 [87]) | 1.16 | 0.00016 |
Cathepsin H | Ctsh | Cysteine protease that may be involved in tumor progression (Schweiger 2004 [88]) | 1.28 | 0.0099 |
Cathepsin K | Ctsk | Cysteine protease that degrades type 1 collagen (Bone 2004 [89]) | 1.71 | 0.00016 |
Cathepsin L | Ctsl | Cysteine protease that processes protryptase to mature tryptase (Le 2011a [86]) | 1.09 | 0.00016 |
Cathepsin S | Ctss | Cysteine protease linked to inflammatory processes such as atherosclerosis, asthma, and atopic dermatitis [20] | 1.28 | 0.00016 |
Cathepsin Z | Ctsz | Cysteine protease involved in enhanced metastasis in various cancers (Wang 2011 [90]) | 1.02 | 0.00016 |
Cathepsin E | Ctse | Aspartic protease that processes procarboxypeptidase (Henningsson 2005 [91]) | −2.05 | 0.00016 |
Cathepsin F | Ctsf | Cysteine protease most notably found in neural tissue (Tang 2006 [92]) | −2.46 | 0.00016 |
Cathepsin O | Ctso | Cysteine protease with endoprotease activity (Zhang 2015 [93]) | −1.09 | 0.00016 |
B-hexosaminidase subunit alpha | Hexa | Alpha subunit of the lysosomal hydrolase B-hexosaminidase, an important enzyme in defense against pathogens (Fukuishi 2014 [94]) | 0.32 | 0.0038 |
Phosphoribosyl pyrophosphate synthetase 1 | Prps1 | Key enzyme involved in histidine and tryptophan synthesis [68, 44] | 2.45 | 0.00016 |
Phosphoribosyl pyrophosphate synthetase 2 | Prps2 | Key enzyme involved in histidine and tryptophan synthesis [68, 44] | 0.54 | 0.00074 |
Tryptophan hydroxylase 1 | Tph1 | Key enzyme in the synthesis of serotonin from tryptophan (Nowak 2012 [49]) | 0.55 | 0.0011 |