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Table 1 Expression of genes in female BMMCs relative to male BMMCs, involved in forming immune mediators stored in mast cell granules

From: Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress

Gene name Gene symbol Comments Statistics
Log2 fold change q value
Tumor necrosis factor Tnf Proinflammatory cytokine stored in preformed mast cell granules (Gordon & Galli 1990 [81]) 3.48 0.00016
Mast cell protease 1 Mcpt1 B-chymase involved in maintaining granule structure (Wastling 1998 [82]) and inflammation at mucosal sites [41] 2.70 0.015
Mast cell protease 2 Mcpt2 Enzymatically inactive chymase without known function (Caughley 2011 [83]) 0.64 0.00016
Mast cell protease 4 Mcpt4 Functional equivalent to human mast cell chymase (Caughley 2015 [43]) 0.39 0.037
Mast cell protease 8 Mcpt8 Serine protease more closely related to granzymes and cathepsin G than chymases (Lutzelschwab 1998 [84]) 1.71 0.00016
Tryptase beta 2 Tpsb2 Serine protease important for pathology in a variety of inflammatory conditions (Payne 2004 [85]) −1.35 0.00016
Cathepsin B Ctsb Cysteine protease that processes protryptase to mature tryptase (Le 2011a [86]) 0.31 0.015
Cathepsin C Ctsc Cysteine protease that is an upstream activator of tryptases, chymases, and cathepsin G (Caughley 2015 [43]) 0.99 0.00016
Cathepsin G Ctsg Serine protease with tryptic and chymotryptic activity (Caughley 2007 [87]) 1.16 0.00016
Cathepsin H Ctsh Cysteine protease that may be involved in tumor progression (Schweiger 2004 [88]) 1.28 0.0099
Cathepsin K Ctsk Cysteine protease that degrades type 1 collagen (Bone 2004 [89]) 1.71 0.00016
Cathepsin L Ctsl Cysteine protease that processes protryptase to mature tryptase (Le 2011a [86]) 1.09 0.00016
Cathepsin S Ctss Cysteine protease linked to inflammatory processes such as atherosclerosis, asthma, and atopic dermatitis [20] 1.28 0.00016
Cathepsin Z Ctsz Cysteine protease involved in enhanced metastasis in various cancers (Wang 2011 [90]) 1.02 0.00016
Cathepsin E Ctse Aspartic protease that processes procarboxypeptidase (Henningsson 2005 [91]) −2.05 0.00016
Cathepsin F Ctsf Cysteine protease most notably found in neural tissue (Tang 2006 [92]) −2.46 0.00016
Cathepsin O Ctso Cysteine protease with endoprotease activity (Zhang 2015 [93]) −1.09 0.00016
B-hexosaminidase subunit alpha Hexa Alpha subunit of the lysosomal hydrolase B-hexosaminidase, an important enzyme in defense against pathogens (Fukuishi 2014 [94]) 0.32 0.0038
Phosphoribosyl pyrophosphate synthetase 1 Prps1 Key enzyme involved in histidine and tryptophan synthesis [68, 44] 2.45 0.00016
Phosphoribosyl pyrophosphate synthetase 2 Prps2 Key enzyme involved in histidine and tryptophan synthesis [68, 44] 0.54 0.00074
Tryptophan hydroxylase 1 Tph1 Key enzyme in the synthesis of serotonin from tryptophan (Nowak 2012 [49]) 0.55 0.0011
  1. Q values <0.05 are considered significant