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Table 1 General characteristics of male and female rats at 6, 12, and 18 months of age

From: Impact of gonadectomy on blood pressure regulation in ageing male and female rats

General characteristics

6 months

12 months

18 months

Three-way ANOVA

F-INTACT

F-GONADX

M-INTACT

M-GONADX

F-INTACT

F-GONADX

M-INTACT

M-GONADX

F-INTACT

F-GONADX

M-INTACT

M-GONADX

 

BW (g)

264.7 ± 18.1

287.8 ± 19.4

425.1 ± 11.8

398 ± 18.1

295.9 ± 20.9

350.6 ± 20.9

504.3 ± 18.3

427.1 ± 18.1

372.4 ± 18.1

422.1 ± 18.1

627.1 ± 24.3

533.4 ± 18.1

6 < 12 < 18***

F < M***; Sex*GONADX***

Kidney left (g)

0.8 ± 0.05

0.9 ± 0.05

1.4 ± 0.05

1.0 ± 0.05

1.1 ± 0.07

0.9 ± 0.07

1.5 ± 0.05

1.1 ± 0.05

1.0 ± 0.05

1.0 ± 0.05

1.5 ± 0.05

1.1 ± 0.05

6 < 12,18***; F < M***; Sham > GONADX***; Gender*GONADX***

Heart (g)

0.9 ± 0.06

0.9 ± 0.06

1.5 ± 0.06

1.1 ± 0.06

1.2 ± 0.06

0.9 ± 0.07

1.2 ± 0.06

1.0 ± 0.06

1.1 ± 0.06

1.0 ± 0.06

1.5 ± 0.06

1.2 ± 0.06

6 > 12 < 18***; F < M***; Sham > GONADX***; Gender*GONADX***

Urine volume (ml/24 h)

11.0 ± 1

9.9 ± 1

11.1 ± 1

9.7 ± 1

13.4 ± 1

10.1 ± 2

10.1 ± 1

10. ± 1

10.9 ± 1

7.9 ± 1

11.3 ± 1

15.2 ± 1

Sex*GONADX*, Sex*Age*

Water intake (ml/24 h)

27.5 ± 2

18.3 ± 2

22.8 ± 2

20.6 ± 2

26.2 ± 3

20.9 ± 3

23.6 ± 2

21.1 ± 2

24.9 ± 2

18.9 ± 2

22.1 ± 2

24.4 ± 2

Sham > GONADX***, Sex*GONADX*

  1. Animals underwent sham (INTACT) or ovariectomy or castration (GONADX) surgery at 10 weeks of postnatal age. The three-way ANOVA assessed the main factor effects of age, sex steroid and surgery, with Tukey HSD post hoc analysis where applicable. Data are presented as mean ± SEM for n = 8 animal per group
  2. FI female INTACT, FG female GONADX, MI male INTACT, MG male GONADX,
  3. *P < 0.05; ***P < 0.001