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Table 3 Relative mRNA levels of cytokines in inguinal and perigonadal adipose tissue at postnatal days (PND) 10, 21, 30, 50, 85, and 150 in male (M) and female (F) rats raised in litters (L) 4 or 12 pups

From: Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens

  Il1β mRNA inguinal IL6 mRNA inguinal TNFα mRNA inguinal Il1β mRNA perigonadal IL6 mRNA perigonadal TNFα mRNA perigonadal
ML12PND10d 100.0 ± 21.3 100.0 ± 10.5 100.0 ± 10.5 TNA TNA TNA
ML4PND10d 100.5 ± 29.6 99.6 ± 56.6 88.9 ± 13.2 TNA TNA TNA
FL12PND10d 156.4 ± 44.6 94.9 ± 22.4 89.8 ± 12.3 TNA TNA TNA
FL4PND10d 32.4 ± 13.3a 38.7 ± 12.1 54.3 ± 11.1 TNA TNA TNA
ML12PND21d 100.0 ± 55.4 100.0 ± 38.7 100.0 ± 28.9 100.0 ± 23.7 100.0 ± 18.5 100.0 ± 21.5
ML4PND21d 42.5 ± 9.3 19.3 ± 1.7a 95.0 ± 25.7 70.3 ± 21.5 339.8 ± 73.8a 161.4 ± 53.6
FL12PND21d 97.8 ± 42.5 112.3 ± 46.6 142.1 ± 32.9 18.4 ± 4.7b 72.8 ± 20.1 50.2 ± 13.8
FL4PND21d 51.3 ± 23.6 20.7 ± 8.2a 41.7 ± 6.3 36.2 ± 8.1 331.0 ± 79.9a 75.4 ± 13.2
ML12PND85 BLD BLD BLD 100.0 ± 42.1 100.0 ± 28.9 100.0 ± 28.8
ML4PND85 BLD BLD BLD 70.0 ± 19.3 124.3 ± 30.3 124.3 ± 30.3
FL12PND85 BLD BLD BLD 47.7 ± 29.1 25.5 ± 20.1b 31.8 ± 24.7b
FL4PND85 BLD BLD BLD 51.0 ± 23.5 22.9 ± 12.4b 15.8 ± 9.1 b
ML12PND150 BLD BLD BLD 100.0 ± 29.5 BLD 100.0 ± 39.5
ML4PND150 BLD BLD BLD 80.5 ± 37.0 BLD 450.5 ± 186.6 a
FL12PND150 BLD BLD BLD 703.9 ± 142.6b BLD 211.0 ± 49.4
FL4PND150 BLD BLD BLD 617.3 ± 145.8b BLD 256.4 ± 65.2
  1. N = 5–6 in each experimental group at each age
  2. TNA tissue not available, BLD below limit of detection
  3. aDifferent from rats of same age and sex (litter effect)
  4. bDifferent from males of same age and litter size
  5. cDifferent from preceding age (same sex and litter size)
  6. dNon-fasting samples
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