Expression profile of androgen-modulated microRNAs in the fetal murine lung

Table 3 Androgen-regulated miRNAs and their corresponding mRNA target(s) on GD 17.0 classified according to molecular functions

Molecular function	Gestational day 17.0
Molecular function	miRNA	mRNA target
Steroid binding	mmu-miR-126-5p	Igf1
	mmu-miR-215	Igf1
Phospholipid binding	mmu-miR-126-5p	Ogt; Pitpnb
	mmu-miR-291a-3p	Wdr45
	mmu-let-7f-2-3p	Col4a3bp
	mmu-let-7b-3p	Pik3c2a; Sbf2; Col4a3bp
SMAD binding	mmu-miR-1306-5p	Zeb2
	mmu-miR-215	Zeb2
Growth factor binding	mmu-miR-215	Col5a1
	mmu-miR-449a	Pdgfra
	mmu-miR-1249-5p	Col5a1
Steroid hormone receptor binding	mmu-miR-1955-5p	Pik3r1
Steroid hormone receptor activity	mmu-miR-291a-3p	Nr2f2
	mmu-miR-362-3p	Nr2c2
	mmu-miR-467b	Nr2f2
	mmu-miR-467d	Nr2f2
	mmu-miR-467h	Nr2f2
	mmu-miR-432	Rorb
Beta-catenin binding	mmu-miR-687	Apc
	mmu-miR-449a	Tbl1xr1
	mmu-let-7f-2-3p	Cd2ap
Retinoic acid binding	mmu-miR-291a-3p	Nr2f2
	mmu-miR-467b	Nr2f2
	mmu-miR-467d	Nr2f2
	mmu-miR-467h	Nr2f2
Transcription factor binding	mmu-miR-3078	Creb1; Tle4; Meis2; Ddx3x
	mmu-miR-465c-3p	Ddx3x
	mmu-miR-291a-3p	E2f2
	mmu-miR-467b	E2f2
	mmu-miR-467d	E2f2
	mmu-miR-467h	E2f2
	mmu-miR-212-3p	Foxo3
	mmu-miR-362-3p	Kdm5c; Trip12
	mmu-miR-432	Kdm5c; Rorb
	mmu-miR-1195	Meis2
	mmu-miR-126-5p	Nfya; Zeb1; Ppargc1a; Pbx1
	mmu-miR-687	Nfya
	mmu-let-7b-3p	Tle4

Italicized data are upregulated by flutamide; boldface data are downregulated by flutamide

ISSN: 2042-6410