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Table 1 SNPs highly associated with melanoma risk in sex-stratified analysis

From: Sex-specific genetic effects associated with pigmentation, sensitivity to sunlight, and melanoma in a population of Spanish origin

     Melanoma
     Female Male Sex-diff
Gene SNP ID Chr mA P value OR P value OR P value
AP3B1 rs11742673 5 A 0.0020 1.43 (1.14–1.80) 0.88 0.98 (0.75–1.28) 0.0210
CDK2/SILV rs2069398 12 A 3.03E−4 0.47 (0.31–0.71) 0.06 0.60 (0.35–1.03) 0.0016
F2RL1 rs2242991 5 G 0.56 0.92 (0.68–1.22) 0.0076 1.61 (1.13–2.29) 0.0067
GPR143 rs2521667 X G 0.46 0.89 (0.67–1.20) 7.04E−4 1.89 (1.30–2.74) 7.85E−4
  rs2732872 X C 0.78 0.96 (0.73–1.27) 8.43E−4 1.81 (1.27–2.57) 0.0052
KIT rs6554198 4 G 0.46 0.92 (0.73–1.15) 0.0027 0.67 (0.51–0.87) 0.07
MYO7A rs3758708 11 A 0.20 1.30 (0.87–1.95) 4.12E−4 2.38 (1.46–3.90) 0.0480
RAB38 rs524121 11 C 0.0086 0.51 (0.30–0.85) 0.36 1.32 (0.73–2.38) 0.0210
RGS20 rs6981243 8 C 0.38 0.90 (0.71–1.14) 0.0021 0.66 (0.51–0.86) 0.0490
SLC45A2 rs35414 5 T 0.03 0.77 (0.61–0.97) 0.0018 0.66 (0.51–0.85) 0.39
  rs35415 5 A 0.03 0.78 (0.62–0.97) 0.0080 0.70 (0.54–0.91) 0.35
TYR rs1042602 11 A 0.35 1.11 (0.89–1.40) 0.0047 0.68 (0.53–0.89) 0.0081
  rs12270717 11 C 0.60 1.07 (0.82–1.40) 0.0032 1.56 (1.16–2.09) 0.09
  rs17793678 11 T 0.32 1.14 (0.88–1.49) 0.0036 1.55 (1.15–2.08) 0.26
  rs2186640 11 G 0.39 0.90 (0.71–1.15) 9.20E−4 1.57 (1.20–2.05) 0.0380
  rs5021654 11 C 0.47 0.92 (0.72–1.16) 2.03E−4 1.66 (1.27–2.17) 0.0014
  1. Entries in italics indicate statistically significant results
  2. SNP single nucleotide polymorphism, Chr chromosome, mA minor allele, OR odds ratio per minor allele, CI confidence interval, Sex-diff sex-differentiated meta-regression estimate test