| | | | |
Melanoma
|
|---|
| | | | |
Female
|
Male
|
Sex-diff
|
|---|
|
Gene
|
SNP ID
|
Chr
|
mA
|
P value
|
OR
|
P value
|
OR
|
P value
|
|---|
|
AP3B1
|
rs11742673
|
5
|
A
|
0.0020
|
1.43 (1.14–1.80)
|
0.88
|
0.98 (0.75–1.28)
|
0.0210
|
|
CDK2/SILV
|
rs2069398
|
12
|
A
|
3.03E−4
|
0.47 (0.31–0.71)
|
0.06
|
0.60 (0.35–1.03)
|
0.0016
|
|
F2RL1
|
rs2242991
|
5
|
G
|
0.56
|
0.92 (0.68–1.22)
|
0.0076
|
1.61 (1.13–2.29)
|
0.0067
|
|
GPR143
|
rs2521667
|
X
|
G
|
0.46
|
0.89 (0.67–1.20)
|
7.04E−4
|
1.89 (1.30–2.74)
|
7.85E−4
|
| |
rs2732872
|
X
|
C
|
0.78
|
0.96 (0.73–1.27)
|
8.43E−4
|
1.81 (1.27–2.57)
|
0.0052
|
|
KIT
|
rs6554198
|
4
|
G
|
0.46
|
0.92 (0.73–1.15)
|
0.0027
|
0.67 (0.51–0.87)
|
0.07
|
|
MYO7A
|
rs3758708
|
11
|
A
|
0.20
|
1.30 (0.87–1.95)
|
4.12E−4
|
2.38 (1.46–3.90)
|
0.0480
|
|
RAB38
|
rs524121
|
11
|
C
|
0.0086
|
0.51 (0.30–0.85)
|
0.36
|
1.32 (0.73–2.38)
|
0.0210
|
|
RGS20
|
rs6981243
|
8
|
C
|
0.38
|
0.90 (0.71–1.14)
|
0.0021
|
0.66 (0.51–0.86)
|
0.0490
|
|
SLC45A2
|
rs35414
|
5
|
T
|
0.03
|
0.77 (0.61–0.97)
|
0.0018
|
0.66 (0.51–0.85)
|
0.39
|
| |
rs35415
|
5
|
A
|
0.03
|
0.78 (0.62–0.97)
|
0.0080
|
0.70 (0.54–0.91)
|
0.35
|
|
TYR
|
rs1042602
|
11
|
A
|
0.35
|
1.11 (0.89–1.40)
|
0.0047
|
0.68 (0.53–0.89)
|
0.0081
|
| |
rs12270717
|
11
|
C
|
0.60
|
1.07 (0.82–1.40)
|
0.0032
|
1.56 (1.16–2.09)
|
0.09
|
| |
rs17793678
|
11
|
T
|
0.32
|
1.14 (0.88–1.49)
|
0.0036
|
1.55 (1.15–2.08)
|
0.26
|
| |
rs2186640
|
11
|
G
|
0.39
|
0.90 (0.71–1.15)
|
9.20E−4
|
1.57 (1.20–2.05)
|
0.0380
|
| |
rs5021654
|
11
|
C
|
0.47
|
0.92 (0.72–1.16)
|
2.03E−4
|
1.66 (1.27–2.17)
|
0.0014
|
- Entries in italics indicate statistically significant results
-
SNP single nucleotide polymorphism, Chr chromosome, mA minor allele, OR odds ratio per minor allele, CI confidence interval, Sex-diff sex-differentiated meta-regression estimate test
