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Table 6 Two-way ANOVA for univariate and pairwise comparisons between gender, estrous cycle stages, and exposure for STAT3 Tyrosine 705 phosphorylation expression

From: Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation

Univariate tests: dependent variable: STAT3 Tyrosine 705
    df F Sig. Partial η2
Analysis of gender and exposure Exposure FA 1, 52 0.001 1.000 0.001
Ozone 1, 52 24.800 <0.0005 0.323
Sex F 1, 52 60.448 <0.0005 0.538
M 1, 52 162.686 <0.0005 0.758
Analysis of female estrous cycle stages and exposure Estrous cycle stage Non-proestrus 1, 28 58.045 <0.0005 0.675
Proestrus 1, 28 50.192 <0.0005 0.642
Exposure FA 1, 28 15.759 <0.0005 0.360
Ozone 1, 28 11.804 0.002 0.297
Pairwise comparisons: dependent variable: STAT3 Tyrosine 705
    (I) Sex (J) Sex Mean difference (I–J) 95 % CI for difference
Lower bound Upper bound
Analysis of gender and exposure Exposure FA M F 1.429E−8 0.663 0.663
Ozone M F 1.645 0.982 2.308
Sex F Ozone FA 2.569 1.906 3.232
M Ozone FA 4.214 3.551 4.877
Analysis of female estrous cycle stages and exposure Estrous cycle stage Non-proestrus Ozone FA 1.185 0.866 1.504
Proestrus Ozone FA 1.102 0.783 1.421
Exposure FA Proestrus Non-proestrus 0.617 0.299 0.936
Ozone Proestrus Non-proestrus 0.534 0.216 0.853