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Table 4 Two-way ANOVA for univariate and pairwise comparisons between gender, estrous cycle stages, and exposure for STAT3 expression

From: Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation

Univariate tests: dependent variable: STAT3
    df F Sig. Partial η2
Analysis of gender and exposure Exposure FA 1, 52 0.031 0.862 0.001
Ozone 1, 52 4.220 0.045 0.075
Sex F 1, 52 0.152 0.698 0.003
M 1, 52 2.217 0.143 0.041
Analysis of female estrous cycle stages and exposure Estrous cycle stage Non-proestrus 1, 24 1.916 0.179 0.074
Proestrus 1, 24 16.113 0.001 0.402
Exposure FA 1, 24 0.087 0.770 0.004
Ozone 1, 24 32.414 < .0005 0.575
Pairwise comparisons: dependent variable: STAT3
    (I) Sex (J) Sex Mean difference (I–J) 95 % CI for difference
Lower bound Upper bound
Analysis of gender and exposure Exposure FA F M 0.012 0.120 0.143
Ozone F M 0.135 0.003 0.267
Sex F Ozone FA 0.026 0.106 0.157
M FA Ozone 0.098 0.034 0.230
Analysis of female estrous cycle stages and exposure Estrous cycle stage Non-proestrus FA Ozone 0.143 0.070 0.356
Proestrus Ozone FA 0.414 0.201 0.628
Exposure FA Proestrus Non-proestrus 0.030 0.183 0.244
Ozone Proestrus Non-proestrus 0.588 0.375 0.801