Fig. 5

SRY blood pressure regulation through androgen receptor and the renin-angiotensin system. a Testosterone-dependent synergistic regulation between SRY and AR is altered by mutations to SRY at the location that separates Sry3 (T) and all other rat and mammalian SRY sequences (P). b Delivery of the Sry3 expression vector (open circle) to the kidney of WKY male rats at day 0 significantly increased blood pressure relative to a control (closed circle) 14 days after vector electroporation. Olmesartan, a RAS inhibitor, administered to control and half of the Sry3-treated animals (closed triangle) at day 14, significantly decreases blood pressure to the same value in both groups. Following removal of olmesartan at day 17, blood pressure increased more rapidly in the Sry3-treated group (closed triangle). Error bars are shown as the SEM of three to four independent animals with asterisk representing a P < 0.05 for blood pressure between the Sry3 and control vector electroporated animals