From: Sex differences in porcine left ventricular myocardial remodeling due to right ventricular pacing
Variables (units) | Sex | HF groups | Interactions (sex and HF groups) |
---|---|---|---|
F p | F p | F p | |
LVEF (%) | 0.85 0.36 | 9.59 < 0.001 | 1.06 0.38 |
LVEDV (ml) | 6.61 0.02 | 8.04 < 0.001 | 2.51 0.08 |
LVEDV, relative increase (%) | 0.26 0.61 | 3.83 0.019 | 1.74 0.18 |
LA/Ao | 0.00 0.95 | 14.79 < 0.001 | 1.71 0.18 |
RWTd | 0.94 0.34 | 3.59 0.02 | 0.64 0.59 |
Em/Am | 0.11 0.74 | 0.20 0.89 | 0.25 0.86 |
BNP, mRNA (AU) | 7.16 0.01 | 3.36 0.03 | 2.07 0.12 |
GATA4, mRNA (AU) | 5.29 0.03 | 1.22 0.32 | 1.04 0.39 |
TGF-β1, mRNA (AU) | 3.43 0.07 | 0.88 0.46 | 0.70 0.56 |
MMP9, mRNA (AU) | 0.06 0.81 | 2.49 0.08 | 1.81 0.16 |
TIMP1, mRNA (AU) | 0.68 0.42 | 1.59 0.21 | 0.74 0.53 |
NGAL, mRNA (AU) | 4.65 0.04 | 1.00 0.40 | 1.65 0.20 |
Col1A1, mRNA (AU) | 3.54 0.07 | 2.67 0.06 | 0.72 0.55 |
Col1A2, mRNA (AU) | 5.43 0.03 | 2.51 0.08 | 1.42 0.26 |
Col3A1, mRNA (AU) | 0.22 0.65 | 3.68 0.02 | 0.48 0.70 |
Water soluble collagen (μg/mg wet tissue) | 5.22 0.03 | 2.59 0.08 | 0.76 0.53 |
Total recoverable collagen (μg/mg wet tissue) | 0.63 0.43 | 0.78 0.51 | 1.59 0.21 |
Total gelatinolytic activity (AU) | 15.59 0.001 | 1.02 0.40 | 0.46 0.71 |
Cross-sectional cardiomyocyte diameter (μm) | 5.84 0.02 | 0.17 0.92 | 1.78 0.34 |