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Table 5 Male-only whole-brain activation (n = 12)

From: Sex differences in psychophysical and neurophysiological responses to pain in older adults: a cross-sectional study

SPM contrast Cluster region Volume Peak T MNI coordinates
subregions (BA) (mm3) x y z
Moderate pain > warmth Cluster 1: right cerebrum   5.50 40 −2 −22
  Middle frontal gyrus 13,424   6 40 39
  Inferior frontal gyrus 13,152   47 38 −9
  Superior frontal gyrus 9408   1 4 63
  Right insula (13) 6824   35 8 −12
  Superior temporal gyrus (22) 4224   59 −36 21
  Right premotor cortex (6) 4080   16 16 62
  Right supplemental motor area (6) 3440   15 22 62
  Inferior frontal gyrus (47) 2744   50 34 −10
  Dorsolateral prefrontal cortex (9) 2576   45 29 33
  Dorsal anterior cingulate cortex (32) 2392   11 38 21
  Precentral gyrus 1936   55 5 8
  Anterior prefrontal cortex (10) 1632   24 55 27
  Right putamen 1568   24 14 −5
  Temporopolar area (38) 1040   41 23 −25
  Caudate head 560   5 9 −3
  Orbitofrontal area (11) 536   27 25 −15
  Putamen 536   −23 12 −3
  Middle temporal gyrus (21) 184   59 −22 −14
  Subgenual cingulate cortex (25) 152   5 12 −8
  Parahippocampal gyrus (34) 128   34 −4 −23
  Cluster 2: right cerebrum   5.70 60 −18 20
  Superior temporal Gyrus (22) 6120   58 1 −4
  Middle temporal gyrus (21) 3376   56 8 −18
  Supramarginal gyrus (40) 3256   58 −41 32
  Right postcentral gyrus 2032   58 −20 20
  Insula (13) 536   41 −7 2
  Angular gyrus (39) 368   39 −56 22
  Secondary somatosensory cortex (42) 280   62 −35 20
  Right fusiform gyrus 160   47 −28 −19
  1. One-sample male only analysis. Significant clusters were derived using 3dClustSim and the intrinsic smoothness of the data to define corrected whole-brain cluster thresholds as those having a voxel level p = 0.05, cluster volume 1659 voxels, volume >120 mm3, and family wise error corrected p = 0.05. Areas are reported with the parent cluster first defined by Peak T, followed by subregions within each cluster (MNI coordinates of subregions are approximate)
  2. SPM Statistical Parametric Mapping, BA Brodmann area, MNI Montreal Neuroimaging Institute