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Table 5 Male-only whole-brain activation (n = 12)

From: Sex differences in psychophysical and neurophysiological responses to pain in older adults: a cross-sectional study

SPM contrast

Cluster region

Volume

Peak T

MNI coordinates

subregions (BA)

(mm3)

x

y

z

Moderate pain > warmth

Cluster 1: right cerebrum

 

5.50

40

−2

−22

 

Middle frontal gyrus

13,424

 

6

40

39

 

Inferior frontal gyrus

13,152

 

47

38

−9

 

Superior frontal gyrus

9408

 

1

4

63

 

Right insula (13)

6824

 

35

8

−12

 

Superior temporal gyrus (22)

4224

 

59

−36

21

 

Right premotor cortex (6)

4080

 

16

16

62

 

Right supplemental motor area (6)

3440

 

15

22

62

 

Inferior frontal gyrus (47)

2744

 

50

34

−10

 

Dorsolateral prefrontal cortex (9)

2576

 

45

29

33

 

Dorsal anterior cingulate cortex (32)

2392

 

11

38

21

 

Precentral gyrus

1936

 

55

5

8

 

Anterior prefrontal cortex (10)

1632

 

24

55

27

 

Right putamen

1568

 

24

14

−5

 

Temporopolar area (38)

1040

 

41

23

−25

 

Caudate head

560

 

5

9

−3

 

Orbitofrontal area (11)

536

 

27

25

−15

 

Putamen

536

 

−23

12

−3

 

Middle temporal gyrus (21)

184

 

59

−22

−14

 

Subgenual cingulate cortex (25)

152

 

5

12

−8

 

Parahippocampal gyrus (34)

128

 

34

−4

−23

 

Cluster 2: right cerebrum

 

5.70

60

−18

20

 

Superior temporal Gyrus (22)

6120

 

58

1

−4

 

Middle temporal gyrus (21)

3376

 

56

8

−18

 

Supramarginal gyrus (40)

3256

 

58

−41

32

 

Right postcentral gyrus

2032

 

58

−20

20

 

Insula (13)

536

 

41

−7

2

 

Angular gyrus (39)

368

 

39

−56

22

 

Secondary somatosensory cortex (42)

280

 

62

−35

20

 

Right fusiform gyrus

160

 

47

−28

−19

  1. One-sample male only analysis. Significant clusters were derived using 3dClustSim and the intrinsic smoothness of the data to define corrected whole-brain cluster thresholds as those having a voxel level p = 0.05, cluster volume 1659 voxels, volume >120 mm3, and family wise error corrected p = 0.05. Areas are reported with the parent cluster first defined by Peak T, followed by subregions within each cluster (MNI coordinates of subregions are approximate)
  2. SPM Statistical Parametric Mapping, BA Brodmann area, MNI Montreal Neuroimaging Institute