Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions

Inoshita, Masatoshi; Numata, Shusuke; Tajima, Atsushi; Kinoshita, Makoto; Umehara, Hidehiro; Yamamori, Hidenaga; Hashimoto, Ryota; Imoto, Issei; Ohmori, Tetsuro

doi:10.1186/s13293-015-0029-7

Biology of Sex Differences

Table 1 Top 20 autosomal CpG sites with significant sex differences

From: Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions

						First set				Second set
Target ID	UCSC RefGene name	Chromosome	Position^a	Relation to UCSC CpG island	UCSC RefGene group	Mean β value of male	Mean β value of female	Sex average difference of β value	Sex p value	Mean β value of male	Mean β value of female	Sex average difference of β value	Sex p value
cg12691488		1	2.4E +08	CGI	Intergenic	0.352	0.171	0.180	2.26E-38	0.263	0.111	0.152	2.11E-03
cg03618918		1	1.6E +08	Others	Intergenic	0.790	0.691	0.099	6.38E-37	0.825	0.745	0.079	3.04E-03
cg17238319	RFTN1	3	1.6E +07	Others	Gene body	0.660	0.788	−0.128	6.88E-34	0.703	0.816	−0.113	5.19E-02
cg25304146	WBP11P1	18	3E +07	Others	Gene body	0.630	0.550	0.081	1.31E-32	0.704	0.604	0.100	5.78E-02
cg03691818	KRT77	12	5.3E +07	Others	Gene body	0.043	0.178	−0.134	3.25E-32	0.052	0.254	−0.202	7.13E-04
cg17232883		11	5.9E +07	Others	Intergenic	0.076	0.157	−0.081	4.72E-31	0.056	0.123	−0.067	1.42E-04
cg25568337	ARID1B	6	1.6E +08	Others	Promoter	0.164	0.258	−0.093	1.07E-29	0.152	0.297	−0.145	1.15E-04
cg04946709	LOC644649	16	6E +07	CGI	Gene body	0.805	0.631	0.175	1.37E-29	0.823	0.499	0.324	8.79E-05
cg22266749	COL25A1	4	1.1E +08	CGI	Promoter	0.192	0.093	0.099	2.77E-27	0.229	0.107	0.122	1.52E-02
cg12177922	HAX1	1	1.5E +08	CGI	Promoter	0.207	0.297	−0.090	4.68E-27	0.161	0.236	−0.074	3.68E-02
cg23719534		15	1E +08	CGI	Intergenic	0.859	0.952	−0.093	6.67E-27	0.858	0.949	−0.091	3.87E-03
cg20299935		17	2.2E +07	Others	Intergenic	0.708	0.811	−0.103	1.84E-26	0.740	0.813	−0.073	8.56E-01
cg12052203	B3GNT1	11	6.6E +07	CGI	Promoter	0.172	0.035	0.136	6.19E-26	0.210	0.050	0.160	1.23E-03
cg06710937		13	2.3E +07	CGI	Intergenic	0.062	0.191	−0.129	1.39E-25	0.036	0.173	−0.137	5.72E-04
cg23814743	NICN1	3	4.9E +07	CGI	Promoter	0.239	0.277	−0.038	2.25E-25	0.121	0.158	−0.038	1.81E-03
cg15817705		1	2.1E +08	CGI shore	Intergenic	0.750	0.662	0.088	2.73E-25	0.759	0.683	0.076	3.01E-02
cg03218192	AP2B1	17	3.4E +07	Others	Promoter	0.276	0.365	−0.089	1.30E-24	0.228	0.344	−0.116	2.43E-03
cg07852945	TLE1	9	8.4E +07	CGI	Promoter	0.103	0.177	−0.074	2.58E-24	0.047	0.137	−0.090	1.83E-04
cg23256579	PRR4	12	1.1E +07	Others	Promoter	0.422	0.631	−0.209	2.97E-24	0.363	0.573	−0.210	4.33E-03
cg25294185	RNASEH2C	11	6.5E +07	CGI	Gene body	0.171	0.064	0.107	1.88E-23	0.162	0.086	0.076	6.48E-01

^aPositions refer to Genome Research Consortium human genome build 37 (GRCh37)/UCSC human genome 19 (hg19)

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ISSN: 2042-6410

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