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Table 1 Top 20 autosomal CpG sites with significant sex differences

From: Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions

  First set Second set
Target ID UCSC RefGene name Chromosome Positiona Relation to UCSC CpG island UCSC RefGene group Mean β value of male Mean β value of female Sex average difference of β value Sex p value Mean β value of male Mean β value of female Sex average difference of β value Sex p value
cg12691488   1 2.4E
+08
CGI Intergenic 0.352 0.171 0.180 2.26E-38 0.263 0.111 0.152 2.11E-03
cg03618918   1 1.6E
+08
Others Intergenic 0.790 0.691 0.099 6.38E-37 0.825 0.745 0.079 3.04E-03
cg17238319 RFTN1 3 1.6E
+07
Others Gene body 0.660 0.788 −0.128 6.88E-34 0.703 0.816 −0.113 5.19E-02
cg25304146 WBP11P1 18 3E
+07
Others Gene body 0.630 0.550 0.081 1.31E-32 0.704 0.604 0.100 5.78E-02
cg03691818 KRT77 12 5.3E
+07
Others Gene body 0.043 0.178 −0.134 3.25E-32 0.052 0.254 −0.202 7.13E-04
cg17232883   11 5.9E
+07
Others Intergenic 0.076 0.157 −0.081 4.72E-31 0.056 0.123 −0.067 1.42E-04
cg25568337 ARID1B 6 1.6E
+08
Others Promoter 0.164 0.258 −0.093 1.07E-29 0.152 0.297 −0.145 1.15E-04
cg04946709 LOC644649 16 6E
+07
CGI Gene body 0.805 0.631 0.175 1.37E-29 0.823 0.499 0.324 8.79E-05
cg22266749 COL25A1 4 1.1E
+08
CGI Promoter 0.192 0.093 0.099 2.77E-27 0.229 0.107 0.122 1.52E-02
cg12177922 HAX1 1 1.5E
+08
CGI Promoter 0.207 0.297 −0.090 4.68E-27 0.161 0.236 −0.074 3.68E-02
cg23719534   15 1E
+08
CGI Intergenic 0.859 0.952 −0.093 6.67E-27 0.858 0.949 −0.091 3.87E-03
cg20299935   17 2.2E
+07
Others Intergenic 0.708 0.811 −0.103 1.84E-26 0.740 0.813 −0.073 8.56E-01
cg12052203 B3GNT1 11 6.6E
+07
CGI Promoter 0.172 0.035 0.136 6.19E-26 0.210 0.050 0.160 1.23E-03
cg06710937   13 2.3E
+07
CGI Intergenic 0.062 0.191 −0.129 1.39E-25 0.036 0.173 −0.137 5.72E-04
cg23814743 NICN1 3 4.9E
+07
CGI Promoter 0.239 0.277 −0.038 2.25E-25 0.121 0.158 −0.038 1.81E-03
cg15817705   1 2.1E
+08
CGI shore Intergenic 0.750 0.662 0.088 2.73E-25 0.759 0.683 0.076 3.01E-02
cg03218192 AP2B1 17 3.4E
+07
Others Promoter 0.276 0.365 −0.089 1.30E-24 0.228 0.344 −0.116 2.43E-03
cg07852945 TLE1 9 8.4E
+07
CGI Promoter 0.103 0.177 −0.074 2.58E-24 0.047 0.137 −0.090 1.83E-04
cg23256579 PRR4 12 1.1E
+07
Others Promoter 0.422 0.631 −0.209 2.97E-24 0.363 0.573 −0.210 4.33E-03
cg25294185 RNASEH2C 11 6.5E
+07
CGI Gene body 0.171 0.064 0.107 1.88E-23 0.162 0.086 0.076 6.48E-01
  1. aPositions refer to Genome Research Consortium human genome build 37 (GRCh37)/UCSC human genome 19 (hg19)