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Table 4 Pathway analysis results

From: Age and sex differences in kidney microRNA expression during the life span of F344 rats

Analysis Gene list a Pathway analysis results b Number of miRNAs p value/score
Age effects Young age expression (17 miRNAs) Top tox func: renal inflammation/renal nephritis 3 3.68E-05
Disease and bio func: organismal inj./abnorm. (nonobstruct azoospermia) 5 2.55E-08
cancer (cervical squamous cell carcinoma) 6 1.14E-07
Top network: organismal inj./abnorm., repro. syst. dis., cancer 10 27
Old age expression (22 miRNAs) Top tox func: N/A - -
Disease and bio func: endocrine syst. dis. (non-insul-dep. diab. mellitus) 6 1.13E-07
cancer (pancreatic ductal adenocarcinoma) 4 1.16E-07
cellular movement (invasion of cells) 6 6.20E-05
Top network: cancer, endocrine syst. dis, gastrointestinal dis. 9 22
Sex effects Female > male (17 miRNAs) Top tox func: N/A - -
Disease and bio func: cancer (uterine endometrioid carcinoma) 4 1.19E-09
organismal inj. and abnorm (nonobstruct azoospermia) 5 9.28E-09
endocrine syst disorder (non-insulin-dep diabetes mellitus) 6 1.11E-08
Top network: organismal injury, repro syst dis, cell death and survival 10 27
Male > female (17 miRNAs) Top tox func: renal inflammation/renal nephritis (lupus nephritis) 6 1.93E-10
Disease and bio func: cancer (cervical squamous cell carcinoma) 9 1.61E-18
hematological dis (nasal natural killer cell lymph) 5 1.87E-10
Top network: cancer, organismal inj & abnorm, repro system disorder 11 28
  1. aGene lists are available in Additional file 3.
  2. bIPA was used to identify significantly enriched pathways.