Table 4 Pathway analysis results
From: Age and sex differences in kidney microRNA expression during the life span of F344 rats
Analysis | Gene list a | Pathway analysis results b | Number of miRNAs | p value/score |
|---|---|---|---|---|
Age effects | Young age expression (17 miRNAs) | Top tox func: renal inflammation/renal nephritis | 3 | 3.68E-05 |
Disease and bio func: organismal inj./abnorm. (nonobstruct azoospermia) | 5 | 2.55E-08 | ||
cancer (cervical squamous cell carcinoma) | 6 | 1.14E-07 | ||
Top network: organismal inj./abnorm., repro. syst. dis., cancer | 10 | 27 | ||
Old age expression (22 miRNAs) | Top tox func: N/A | - | - | |
Disease and bio func: endocrine syst. dis. (non-insul-dep. diab. mellitus) | 6 | 1.13E-07 | ||
cancer (pancreatic ductal adenocarcinoma) | 4 | 1.16E-07 | ||
cellular movement (invasion of cells) | 6 | 6.20E-05 | ||
Top network: cancer, endocrine syst. dis, gastrointestinal dis. | 9 | 22 | ||
Sex effects | Female > male (17 miRNAs) | Top tox func: N/A | - | - |
Disease and bio func: cancer (uterine endometrioid carcinoma) | 4 | 1.19E-09 | ||
organismal inj. and abnorm (nonobstruct azoospermia) | 5 | 9.28E-09 | ||
endocrine syst disorder (non-insulin-dep diabetes mellitus) | 6 | 1.11E-08 | ||
Top network: organismal injury, repro syst dis, cell death and survival | 10 | 27 | ||
Male > female (17 miRNAs) | Top tox func: renal inflammation/renal nephritis (lupus nephritis) | 6 | 1.93E-10 | |
Disease and bio func: cancer (cervical squamous cell carcinoma) | 9 | 1.61E-18 | ||
hematological dis (nasal natural killer cell lymph) | 5 | 1.87E-10 | ||
Top network: cancer, organismal inj & abnorm, repro system disorder | 11 | 28 |