Figure 2

Relative renal gene expression. The relative renal gene expression of (A) AT_1aR, (B) AT_1bR, (C) AT₂R, (D) ACE2, and (E) MasR in WT (black bars) and AT₂R-KO (grey bars) adult, aged, and aged-OVX female mice following 14-day infusion of vehicle (0.9% saline s.c.) or AngII (600 ng/kg/min s.c.). Data are presented as mean ± SEM and are expressed relative to the adult WT vehicle-treated group. Data were analyzed using a one-way ANOVA followed by 12 planned post hoc t-tests with Holm-Sidak correction to reduce the risk of type 1 error associated with multiple comparisons. *P < 0.05; **P < 0.01.