Brain responses to smoking cues relative to non-smoking cues. For females crosshairs are centered on the medial orbitofrontal cortex (mOFC), for males crosshairs are centered on the ventral striatum (VS), and for direct comparisons between males and females crosshairs are centered on the left hippocampus/amygdala (H-A). Representative fMRI sagittal, axial, and coronal brain slices analyzed in SPM8 and overlain on the MNI brain. T values range from 3.10 to 4.19, corrected at p < 0.005. Images are displayed neurologically (left is left). An interactive visual display of all brain data in all three planes can be found at http://franklinbrainimaging.com.